PMID: 2484404Apr 1, 1989Paper

Stimulation of mucosal uptake of selenium from selenite by L-cysteine in sheep small intestine

Biological Trace Element Research
R WürmliE Scharrer

Abstract

The influence of cysteine (Cys) on mucosal uptake of 75Se-labeled selenite in sheep midjejunum was investigated using a short-term uptake technique. L-Cys (concn.: 1.0 mmol/L) significantly stimulated uptake of Se from selenite (concn.: 10 mumols/L). The stimulatory effect of L-Cys on mucosal uptake of Se from selenite was Na(+)- and pH-dependent. In the absence of Na+, or at an acidic pH (5.0), the stimulatory effect of L-Cys was abolished. L-alanine and L-lysine, but not L-glutamic acid inhibited uptake of Se from selenite in the presence of L-Cys. Preincubation of mucosal preparations with 10 mmol/L L-Cys produced enhanced mucosal uptake of Se from selenite. It is concluded from these results that L-Cys stimulates absorption of Se from selenite probably by generation of selenodicysteine and maybe cysteine selenopersulfide that are subsequently transported across the intestinal brush border membrane by Na(+)-dependent amino acid carriers. Furthermore, intracellular generation of selenodicysteine might contribute to the uptake of Se from selenite by maintaining the concentration gradient for diffusive uptake of selenite.

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Citations

Apr 1, 1992·Biological Trace Element Research·E SennS Wolffram
Sep 16, 2008·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·A C PappasG Zervas
May 15, 2018·Antioxidants·Evangelos ZoidisGeorgios P Danezis
Sep 22, 2005·Endocrine Reviews·J KöhrleJ E Dumont
Aug 1, 1992·Journal of Inorganic Biochemistry·S C VendelandP D Whanger
Apr 23, 2005·Toxicology and Applied Pharmacology·Christy C Bridges, Rudolfs K Zalups

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