Stimulation of Na:H exchange by insulin

Biophysical Journal
R D Moore

Abstract

In frog skeletal muscle, the increase of intracellular pH (pHi) induced by insulin is correlated with an increase in intracellular Na+ when the sodium pump is inhibited by ouabain. Reversing the Na+ free energy gradient by substituting either Mg2+ or choline for extracellular Na+ converts the effect of insulin to a decrease in pHi, indicating that the action of insulin upon pHi is determined by the Na+ free energy gradient. Moreover, estimates of the Na+ free energy gradient indicate that both the direction and magnitude satisfy the hypothesis that this is the source of energy for the observed changes in pHi. Both the increase in intracellular pH induced by insulin and the associated increase in intracellular Na+ produced by this hormone in the presence of ouabain are blocked by amiloride. This drug also blocks the decrease in pHi by insulin when Mg2+ is substituted for Na+ in the Ringer. In Ringer containing Na+, the increase in pHi by insulin occurs when both metabolic and atmospheric sources of CO2 are eliminated by using a 100% N2 atmosphere. Thus, the mechanism stimulated by insulin is not a Na+-CO3(2-) cotransport system, but is either an Na:H exchange or a Na+-OH- cotransport system which can be inhibited by amiloride. T...Continue Reading

Citations

May 1, 1987·Pflügers Archiv : European journal of physiology·M WeigtH Oberleithner
Jan 1, 1986·The Journal of Membrane Biology·S Grinstein, A Rothstein
Jan 1, 1983·The Journal of Membrane Biology·W F Boron
Nov 1, 1983·Developmental Biology·P PayanB Ciapa
Dec 1, 1993·Steroids·W P MeehanM F Saad
Jan 1, 1988·Comparative Biochemistry and Physiology. A, Comparative Physiology·Y Marunaka
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J PouysségurE Van Obberghen-Schilling
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·P M Rosoff, L C Cantley
May 1, 2008·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Daniel L Levin
May 16, 1988·European Journal of Biochemistry·C FrelinM Lazdunski
Jan 23, 2003·Archives of Disease in Childhood·A P C P CarlottiM L Halperin
Jun 1, 1995·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·J K Shoemaker, A Bonen
Jan 1, 1996·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·R Zhande, R W Brownsey
Feb 1, 1985·The Journal of Clinical Investigation·J P KnochelN W Carter
Apr 1, 1987·The Journal of Clinical Investigation·E A Sims, E Danforth
May 3, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kamel S KamelMitchell L Halperin
May 27, 2003·Diabetes·Robert T C E RobinsonSimon R Heller
May 9, 1992·Biochimica Et Biophysica Acta·S ViniegraC A Rabito
Jun 15, 1982·Biochemical and Biophysical Research Communications·A Le CamM Samson
Jan 1, 1995·Critical Reviews in Clinical Laboratory Sciences·T R Csorba, A L Edwards
Jan 1, 1983·The Journal of Membrane Biology·L E Moore, T D Tsai
Sep 1, 1982·Hypertension·E A Sims
Mar 1, 1993·Hypertension·A M SharmaA Distler
Jan 1, 1989·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M J Fisher, P F Dillon
Jul 1, 1982·Journal of Cellular Physiology·C L MummeryS W de Laat
Jan 1, 1990·Critical Reviews in Toxicology·B HermanJ J Lemasters
Feb 1, 1995·Redox Report : Communications in Free Radical Research·F MarquesM Bicho
May 1, 1992·Hypertension·M Epstein, J R Sowers

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