Nov 27, 2008

Stimulation of neural regeneration in the mouse retina

Proceedings of the National Academy of Sciences of the United States of America
Mike O KarlThomas A Reh

Abstract

Müller glia can serve as a source of new neurons after retinal damage in both fish and birds. Investigations of regeneration in the mammalian retina in vitro have provided some evidence that Müller glia can proliferate after retinal damage and generate new rods; however, the evidence that this occurs in vivo is not conclusive. We have investigated whether Müller glia have the potential to generate neurons in the mouse retina in vivo by eliminating ganglion and amacrine cells with intraocular NMDA injections and stimulating Müller glial to re-enter the mitotic cycle by treatment with specific growth factors. The proliferating Müller glia dedifferentiate and a subset of these cells differentiated into amacrine cells, as defined by the expression of amacrine cell-specific markers Calretinin, NeuN, Prox1, and GAD67-GFP. These results show for the first time that the mammalian retina has the potential to regenerate inner retinal neurons in vivo.

Mentioned in this Paper

Retinal Damage
Gad1 protein, human
CALB2 gene
Neurons
Synovial Cyst
Glutamate Decarboxylase
Retinal Diseases
Calretinin
Neuroglia
N-Methylaspartate

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