Stimulation of NGF production by tryptophan and its metabolites in cultured mouse astroglial cells

Brain Research
L Dong-RyulK Nakano

Abstract

Effects of various amino acids and tryptophan metabolites on the synthesis of nerve growth factor (NGF) in cultured mouse astroglial cells were evaluated. L-Tryptophan stimulated NGF production in a dose-dependent manner. Serotonin and quinolinic acid slightly increased NGF synthesis. L-Kynurenine had a marked stimulatory effect on NGF production at a dose of 10 microM. In contrast, kynurenic acid had no effect on the reaction. L-Glutamine, L-glutamic acid, L-phenylalanine and L-methionine produced no significant change in NGF synthesis. These results were discussed in relation to the treatment of Alzheimer's diseases.

Citations

Jul 11, 2020·International Journal of Tryptophan Research : IJTR·Masatoshi Yamashita
Aug 16, 2006·Neuro-degenerative Diseases·Gilles J GuilleminBruce J Brew
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Viviane Soares Souza LimaJuliana Mozer Sciani

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