PMID: 11932951Apr 5, 2002Paper

Stimulation of nitric oxide synthase in cerebral cortex due to elevated partial pressures of oxygen: an oxidative stress response

Journal of Neurobiology
S R ThomD G Buerk

Abstract

The purpose of this investigation was to determine the impact of elevated partial pressures of O(2) on the steady state concentration of nitric oxide ((*)NO) in the cerebral cortex. Rodents with implanted O(2)- and (*)NO-specific microelectrodes were exposed to O(2) at partial pressures from 0.2 to 2.8 atmospheres absolute (ATA) for up to 45 min. Elevations in (*)NO concentration occurred with all partial pressures above that of ambient air. In rats exposed to 2.8 ATA O(2) the increase was 692 +/- 73 nM (S.E., n = 5) over control. Changes were not associated with alterations in concentrations of nitric oxide synthase (NOS) enzymes. Based on studies with knock-out mice lacking genes for neuronal NOS (nNOS) or endothelial NOS (eNOS), nNOS activity contributed over 90% to total (*)NO elevation due to hyperoxia. Immunoprecipitation studies indicated that hyperoxia doubles the amount of nNOS associated with the molecular chaperone, heat shock protein 90 (Hsp90). Both (*)NO elevations and the association between nNOS and Hsp90 were inhibited in rats infused with superoxide dismutase. Elevations of (*)NO were also inhibited by treatment with the relatively specific nNOS inhibitor, 7 nitroindazole, by the ansamycin antibiotics herbimyc...Continue Reading

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Citations

Aug 11, 2010·Pflügers Archiv : European journal of physiology·Dmitriy N Atochin, Paul L Huang
Oct 16, 2003·Nitric Oxide : Biology and Chemistry·Mikulas ChavkoRichard M McCarron
May 19, 2007·Antioxidants & Redox Signaling·Donald G Buerk
Jul 17, 2008·Antioxidants & Redox Signaling·Zhao-Jun Liu, Omaida C Velazquez
Jan 14, 2011·Plastic and Reconstructive Surgery·Stephen R Thom
May 4, 2007·The Journal of Clinical Investigation·Katherine A GallagherOmaida C Velazquez
Mar 5, 2011·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Pia Lawson-SmithOle Hyldegaard
Dec 27, 2011·Critical Reviews in Biomedical Engineering·Donald G BuerkDov Jaron
Mar 29, 2014·Respiratory Physiology & Neurobiology·Yehuda ArieliAyala Hochman
Apr 16, 2014·Antioxidants & Redox Signaling·Katina M Fosen, Stephen R Thom
Dec 14, 2011·Life Sciences·Edina L CarlileRaymond M Quock
Apr 27, 2010·The Journal of Pain : Official Journal of the American Pain Society·Eunhee ChungRaymond M Quock
Mar 25, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ivan T DemchenkoClaude A Piantadosi
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Oct 19, 2013·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Alexandra C KendallPaul Eggleton
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Dec 6, 2005·Toxicology and Applied Pharmacology·Stephen R ThomDonald Fisher
Jan 30, 2013·Renal Failure·Musa Salmanoglu, Yalçın Onem
Nov 4, 2008·The Journal of Pain : Official Journal of the American Pain Society·Lisa M ZelinskiRaymond M Quock
Sep 8, 2017·International Journal of Molecular Sciences·Laura Terraneo, Michele Samaja
Sep 5, 2009·Neuroreport·Yusuke OhgamiRaymond M Quock
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Feb 20, 2008·The Journal of Biological Chemistry·Stephen R ThomTatyana N Milovanova
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Aug 22, 2007·Neurochemical Research·Ahmet KorkmazAhmet Akin

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