Stimulation of non-sodium-dependent water, electrolyte, and glucose transport in rat small intestine by gum arabic

Digestive Diseases and Sciences
M A WingertzahnR A Wapnir

Abstract

In experimental models of gastroenterological disease, the soluble fiber gum arabic (GA) acts as a proabsorptive adjuvant. This study investigated which specific transport pathway(s) are affected by GA. Rat jejunum was perfused under anesthesia with a standardized oral rehydration solution (ORS) containing D-glucose, with or without GA (2.5 g/liter). In some preparations either phloridizin, a competitive inhibitor of Na+-coupled D-glucose transport, or phloretin, an inhibitor of basolateral glucose transport, were added to the ORS, with or without GA. Diffusion and paracellular transport changes due to GA were evaluated with L-glucose and [14C]polyethlyene glycol 4000 (PEG). GA partially reversed water, Na+, and D-glucose absorption inhibition induced by phloridzin and normalized water and Na+ absorption in the presence of phloretin. GA also increased absorption of water, Na+, and PEG from an L-glucose ORS. The data suggest that GA does not act via Na+ dependent mechanism(s), but stimulates transcellular and/or transjunctional transport pathways; therefore GA may be useful to increase absorption of solutes transported by diffusion.

Citations

Sep 1, 2006·Journal of the American College of Nutrition·Champa N CodipillyRaul A Wapnir
May 9, 2007·Digestive Diseases and Sciences·Raul A WapnirIvana Vancurova
Jun 24, 2011·Journal of the American College of Nutrition·Raul A WapnirFima Lifshitz
Sep 25, 2004·Experimental Biology and Medicine·Khalil U RehmanRaul A Wapnir

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