Stimulation of nonspecific resistance to infection induced by 6-O-acyl muramyl dipeptide analogs in mice.

Infection and Immunity
K MatsumotoI Azuma

Abstract

The experimental system utilized in investigating the correlation between the chemical structures of muramyl peptides and their protective activities in the sepsis type of systemic infections caused by Escherichia coli was applied in evaluating the enhancement of resistance to infection induced by 32 synthetic glycopeptide analogs, including 6-O-acyl derivatives and 1-alpha-O-benzyl derivatives of muramyl dipeptide (N-acetyl muramyl-L-alanyl-D-isoglutamine). In assessing the 6-O-acyl derivatives of muramyl dipeptide, we found that the degree of protective activity was attributable to the kinds of fatty acids introduced. Acylation of the 6-hydroxy group on the muramic acid moiety in muramyl dipeptide with natural mycolic acid or a synthetic fatty acid possessing either an alpha-branched or an alpha-branched, beta-hydroxylated group resulted in a decrease in or a disappearance of the protective activity of muramyl dipeptide. Acylation with a normal fatty acid or an iso fatty acid resulted in a retention or enhancement of muramyl dipeptide activity. The activity of acylated derivatives containing linear fatty acids was stimulated by increasing the chain length up to 18 carbon atoms. The highest degree of protective activity occurr...Continue Reading

References

May 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·L ChedidE Lederer
Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·M ParantL Chedid
Jan 1, 1978·Biochemical Pharmacology·L Chedid, E Lederer
Dec 1, 1978·The Journal of Infectious Diseases·C A DinarelloS M Wolff
May 1, 1979·Infection and Immunity·A TanakaS Kusumoto
Aug 20, 1979·Biochimica Et Biophysica Acta·H U Weltzien
Jul 1, 1979·Infection and Immunity·H TakadaK Yokogawa
Feb 28, 1978·Biochemical and Biophysical Research Communications·Y YamamotoK Onoue
Jul 1, 1977·Proceedings of the Society for Experimental Biology and Medicine·S SpecterL Chedid
Jul 25, 1977·Biochemical and Biophysical Research Communications·A TanakaT Shiba
Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·L ChedidE Lederer
Oct 27, 1975·Biochemical and Biophysical Research Communications·C MerserA Adam
Aug 19, 1974·Biochemical and Biophysical Research Communications·F EllouzE Lederer

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Citations

Apr 1, 1984·Medicinal Research Reviews·A Adam, E Lederer
Jan 1, 1981·Microbiology and Immunology·K MatsumotoI Azuma
Oct 29, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thirumahal SelvananthamThierry Mallevaey
Oct 1, 1987·Agents and Actions·M AkasakiW Tsukada
Dec 5, 2019·Clinical & Translational Immunology·Matthew E GriffinHoward C Hang
Sep 22, 2017·PLoS Pathogens·Stephanie A Ragland, Alison K Criss
May 8, 2021·Frontiers in Immunology·Svetlana V Guryanova, Rahim M Khaitov
Jul 20, 2001·International Immunopharmacology·I Azuma, T Seya
Jan 1, 1992·Antimicrobial Agents and Chemotherapy·O TataraY Niki
Jul 1, 1994·Clinical Microbiology Reviews·A G Johnson
Jan 1, 1989·International Journal of Immunopharmacology·K OnozukaM Nakano
Apr 1, 1983·Infection and Immunity·K N MasihiW Lange
Mar 1, 1986·Infection and Immunity·R V WatersG H Jones

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