Stimulation of osteoclast formation by inflammatory synovial fluid.

Virchows Archiv : an International Journal of Pathology
I E AdamopoulosN A Athanasou

Abstract

Peri-articular bone resorption is a feature of arthritis due to crystal deposition and rheumatoid disease. Under these conditions, the synovial fluid contains numerous inflammatory cells that produce cytokines and growth factors which promote osteoclast formation. The aim of this study was to determine whether inflammatory synovial fluid stimulates the formation of osteoclasts. Synovial fluid from rheumatoid arthritis (RA), pyrophosphate arthropathy (PPA) and osteoarthritis (OA) patients was added to cultures (n=8) of human peripheral blood mononuclear cells (PBMCs) in the presence and absence of macrophage colony-stimulating factor (M-CSF) and the receptor activator of NF-kappaB ligand (RANKL). Osteoclast formation was assessed by the formation of cells positive for tartrate-resistant acid phosphatase (TRAP) and vitronectin receptor (VNR) and the extent of lacunar resorption. The addition of 10% OA, RA and PPA synovial fluid to PBMC cultures resulted in the formation of numerous multinucleated or mononuclear TRAP(+) and VNR(+) cells which were capable of lacunar resorption. In contrast to PBMC cultures incubated with OA synovial fluid, there was marked stimulation of osteoclast formation and resorption in cultures containing i...Continue Reading

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Citations

Feb 20, 2010·Arthritis Research & Therapy·Iannis E AdamopoulosEdward P Bowman
Apr 29, 2009·The Keio Journal of Medicine·Steeve Kwan TatJohanne Martel-Pelletier
Dec 17, 2014·Life Sciences·Samir M AbdelmagidFayez F Safadi
Aug 25, 2015·Autoimmunity Reviews·Maximiliano Javier Jiménez-DalmaroniIannis E Adamopoulos
Feb 20, 2008·Virchows Archiv : an International Journal of Pathology·Lars MorawietzVeit Krenn
Sep 10, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Seung-Jae KimShiva Shahrara

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