Stimulation of p85/RING3 kinase in multiple organs after systemic administration of mitogens into mice

Oncogene
J OstrowskiK Bomsztyk

Abstract

Using an autophosphorylation membrane assay, we examined activation of kinases in different organs after intraperitoneal injections of mitogens and cytokines into mice. In the multiple organs examined administration of either epidermal growth factor (EGF), phorbol 12-myristate 13-acetate (PMA) or interleukin-1beta (IL-1beta) activated a number of kinases. Most notably among those was a kinase of approximately 85 kDa (p85) that was activated by EGF, PMA and IL-1beta in the lung, kidney, brain, liver and heart. The size and properties of this enzyme are indistinguishable from the RING3 kinase that has a very high activity in leukocytes of patients with leukemia. In animals treated with PMA, antibodies against RING3 kinase immunoprecipitated PMA-responsive p85 activity from the lung and brain suggesting that p85 and RING3 kinases are the same enzymes. Activation of p85/RING3 kinase by growth factors in multiple organs might reflect involvement of this enzyme in the pathogenesis of leukemias and other proliferative diseases.

Citations

Jun 18, 1999·Neurochemistry International·K Domańska-JanikJ Ostrowski
Jun 23, 2012·Nature Reviews. Cancer·Anna C Belkina, Gerald V Denis
Oct 18, 2003·Blood·Rebecca J GreenwaldGerald V Denis
Feb 3, 2007·Neurobiology of Aging·Magdalena C PopescoAndrej Rotter
Dec 16, 2003·Biochemical and Biophysical Research Communications·Reinhard KodymElisabeth Ortmann
Feb 12, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Brian L Florence, Douglas V Faller
May 8, 2009·Pediatrics International : Official Journal of the Japan Pediatric Society·Jing Liu, Zhi-Chun Feng

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