PMID: 3761009Aug 1, 1986Paper

Stimulation of pancreatic enzyme secretion by a peptide purified from rat bile-pancreatic juice

The Journal of Nutrition
S FukuokaK Iwai

Abstract

We purified a peptide from rat pancreatic juice that enhances pancreatic enzyme secretion in a manner different from that of exogenous trypsin inhibitors, such as soybean trypsin inhibitor, when it is infused into the rat intestine. In this paper, we present evidence for the release of gut hormone(s) into the blood of rats after intestinal administration of the peptide. In the presence of atropine, an anesthetized rat small intestine was washed out with saline containing soybean trypsin inhibitor (Kunitz type) to eliminate proteases. Under these conditions, the rat small intestine was divided into four equal parts by ligation. Administration of the peptide into the first quarter of the small intestine stimulated pancreatic enzyme secretion. However, administration into the more distal parts did not stimulate the enzyme secretion. Moreover, intravenous injection of 1 mL of plasma from rats in which the peptide had been infused into the duodenum caused stimulation of pancreatic enzyme secretion in the recipient rats. It was suggested that the purified peptide acts in the proximal small intestine and that it stimulates the release of gut hormone(s) into the blood to enhance pancreatic enzyme secretion. These findings support the h...Continue Reading

Citations

Oct 1, 1990·European Journal of Clinical Investigation·U R Fölsch
May 29, 2003·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·R GrafD Bimmler
Sep 14, 1986·Biochemical and Biophysical Research Communications·S FukuokaK Iwai
Apr 25, 2006·Endocrinology and Metabolism Clinics of North America·Rolf Graf, Daniel Bimmler

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