PMID: 11607216Oct 1, 1991Paper

Stimulation of pheromone biosynthesis in the moth Helicoverpa zea: action of a brain hormone on pheromone glands involves Ca2+ and cAMP as second messengers

Proceedings of the National Academy of Sciences of the United States of America
R JurenkaWendell L Roelofs

Abstract

Isolated abdomen and pheromone gland bioassays were utilized to determine the physiological action of the pheromone-biosynthesis-activating neuropeptide (PBAN) in the corn earworm moth Helicoverpa (= Heliothis) zea. An isolated pheromone gland bioassay showed that synthetic PBAN was active at 0.02 pmol, with maximal activity occurring at 0.5 pmol and 60 min of incubation. Second-messenger studies demonstrated that extracellular Ca2+ is necessary for PBAN activity on isolated pheromone glands. The Ca2+ ionophore A23187 stimulated pheromone biosynthesis alone, whereas the Ca2+ channel blockers La3+ and Mn2+ inhibited PBAN activity. However, the organic Ca2+ channel blockers verapamil and nifedipine did not inhibit PBAN activity. Both forskolin and two cAMP analogues stimulated pheromone biosynthesis in the absence of extracellular Ca2+, indicating that Ca2+ may activate an adenylate cyclase. The biogenic amine octopamine did not elicit pheromone production in isolated gland or abdomen bioassays or when injected into intact female moths. Removal of the ventral nerve chord, including the terminal abdominal ganglia in isolated abdomens, did not affect PBAN stimulation of pheromone production. Similar levels of stimulation were found...Continue Reading

References

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Citations

Jan 1, 1993·Archives of Insect Biochemistry and Physiology·A K Raina, J J Menn
Jan 1, 1994·Archives of Insect Biochemistry and Physiology·S B RamaswamyN M Cox
Mar 1, 1996·Insect Biochemistry and Molecular Biology·R Ozawa, S Matsumoto
Jul 1, 1994·Comparative Biochemistry and Physiology. Pharmacology, Toxicology and Endocrinology·R A JurenkaW L Roelofs
Dec 3, 1999·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·A FónagyS Matsumoto
Jul 31, 1998·Insect Biochemistry and Molecular Biology·P W MaW L Roelofs
Aug 11, 2007·Bioscience, Biotechnology, and Biochemistry·J Joe HullShogo Matsumoto
Feb 9, 2010·Bioscience, Biotechnology, and Biochemistry·Shogo Matsumoto
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·T Ichikawa
Jul 31, 2003·Proceedings of the National Academy of Sciences of the United States of America·Man-Yeon ChoiRussell Jurenka
Apr 12, 2002·Archives of Insect Biochemistry and Physiology·WenQi Rosén
Apr 24, 2007·Journal of Insect Physiology·J Joe HullShogo Matsumoto
Jun 9, 2004·Journal of Insect Physiology·Man-Yeon Choi, Russell A Jurenka
Jun 4, 2013·Molecular and Cellular Endocrinology·Man-Yeon ChoiRobert K Vander Meer
Dec 29, 2006·Chemistry & Biodiversity·Akinori HirashimaMorifusa Eto

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