Stimulation of platelet-derived growth factor-induced DNA synthesis by angiotensin II in rabbit vascular smooth muscle cells

Biochemical and Biophysical Research Communications
S ArakiT Yoshimi

Abstract

In cultured rabbit vascular smooth muscle cells (VSMCs), angiotensin II by itself had little mitogenic effect even in the presence of cell-free plasma-derived serum (PDS), but markedly stimulated the platelet-derived growth factor (PDGF)-induced DNA synthesis in the presence of PDS. The maximal extent of DNA synthesis induced by PDGF plus angiotensin II was about twice that induced by PDGF alone. The stimulatory effect of angiotensin II was dose-dependent with the maximal response seen at 1 microM and was inhibited by the specific angiotensin II receptor antagonist, [Sar1, Ile8]angiotensin II. In VSMCs, both PDGF and angiotensin II induced expression of the c-fos gene in dose-dependent manners. In contrast to the synergistic effect of angiotensin II and PDGF on DNA synthesis, they induced expression of the c-fos gene in an additive manner. These results suggest that angiotensin II may act as a growth regulator for VSMCs in addition to acting as a vasoconstrictor.

References

Jun 1, 1977·Journal of Cellular Physiology·D GospodarowiczD L Braun
Aug 19, 1976·The New England Journal of Medicine·R Ross, J A Glomset
Aug 12, 1976·The New England Journal of Medicine·R Ross, J A Glomset
Jan 1, 1985·Annual Review of Biochemistry·T Hunter, J A Cooper
Feb 20, 1986·The New England Journal of Medicine·R Ross
Apr 1, 1986·Circulation Research·S M SchwartzJ H Campbell
Mar 1, 1985·The Journal of Clinical Investigation·B C BerkR W Alexander
Apr 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·R RossL Harker
May 1, 1980·The Journal of Cell Biology·C GajdusekS M Schwartz

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Citations

May 1, 1991·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·C J WelshK McBride
Jan 4, 1993·Neuroscience Letters·Y Shigeri, M Fujimoto
Oct 29, 2000·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·K HayashiH Murakami
Dec 9, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sabine C WolfBernhard R Brehm
Oct 1, 1992·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S J Hirst, C H Twort
Jun 1, 1994·British Journal of Pharmacology·D A WalshJ Wharton
Feb 1, 1993·The Journal of Clinical Investigation·A Tufro-McReddieR A Gomez
Jun 10, 2000·Acta Physiologica Scandinavica·L SchiotzM J Mulvany
Apr 1, 1997·Archives of Physiology and Biochemistry·E I MangiaruaW D McCumbee
Jul 2, 2005·Expert Opinion on Emerging Drugs·J Linde, B H Strauss
Mar 1, 1993·Kidney International·M E Rosenberg, T H Hostetter
Nov 1, 1995·Kidney International·M BensoussanP M Ronco
Sep 30, 1992·Biochemical and Biophysical Research Communications·B TeutschE Clauser
Oct 1, 1992·Pathology·L M Khachigian, C N Chesterman
Nov 16, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Stephanie CoulonHans Van Vlierberghe

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