Stimulation of progesterone and prostaglandin E2 production by lipoxygenase metabolites of arachidonic acid

FEBS Letters
J WangP C Leung

Abstract

The role of several lipoxygenase metabolites of arachidonic acid in the action of luteinizing hormone-releasing hormone (LHRH) on ovarian hormone production was investigated. Like LHRH, treatment of rat granulosa cells with 5-HETE, 5-HPETE, 12-HETE, 15-HETE or 15-HPETE stimulated progesterone (P) and prostaglandin E2 (PGE2) production. 12-HEPE was most potent and stimulated P and PGE2 equally well. By contrast, 5-HETE stimulated P better than PGE2, while 15-HETE was a potent stimulator of PGE2 but not of P. Stimulation of P and PGE2 by LHRH or 12-O-tetradecanoylphorbol 13-acetate (TPA) was further augmented by several HETEs and HPETEs. Like protein kinase C, arachidonic acid metabolites appear to mediate the multiple actions of LHRH in the ovary.

References

Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A L HultingB Samuelsson
Mar 1, 1987·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·L KieselB Runnebaum
Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·H R MorrisJ R Tippins

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Citations

Mar 1, 1991·Molecular and Cellular Endocrinology·M H Majercik, D Puett
Oct 2, 2001·Prostaglandins & Other Lipid Mediators·G Basini, C Tamanini
Jan 16, 2002·Prostaglandins & Other Lipid Mediators·Hiroaki TaniguchiKiyoshi Okuda
Apr 3, 2001·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·K Shen, C A Herman
Jan 1, 1993·Prostaglandins, Leukotrienes, and Essential Fatty Acids·D L BooneP C Leung
Dec 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·D J Fretland, S W Djuric

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