PMID: 1212199Sep 1, 1975Paper

Stimulation of protein synthesis in cultured heart muscle cells by glucose

The Biochemical Journal
M David, Y Avi-Dor

Abstract

Glucose stimulated the rate of incorporation of [3H]leucine into HCLO4-insoluble fraction of cultured rat heart muscle cells under both aerobic and anaerobic conditions. In the aerobic system the incorporation proceeded at a constant rate during 3h of incubation with and without glucose whereas in the anaeorbic system the incorporation ceased after approx. 60 min and could be renewed only by the addition of glucose. No correlation was found to exist between the above effect of glucose on protein synthesis and glucose-dependent changes in the intracellular ATP concentration. The extent of the stimulation of protein synthesis was related to the concentration of glucose. The effect of glucose was suppressed by cycloheximide but was not affected by actinomycin D. Glucose had no effect on the rate of transport of alpha-aminoisobutyric acid. Mannose also stimulated [3H]leucine incorporation. Substances that did not produce lactate were ineffective. Iodoacetate inhibited the stimulatory effect of glucose, but pyruvate, which by itself had no apprecialbe stimulatory action, relieved the inhibition induced by iodoacetate. There was no concomitant change in the concentration of ATP when iodoacetate inhibition was reversed by pyruvate. L-...Continue Reading

Citations

Mar 1, 1979·Journal of Cellular Physiology·N MayorekM Mayer
Jan 1, 1985·Basic Research in Cardiology·J ZähringerG Stäb
Sep 1, 1990·Biochemical Pharmacology·S CastiglioneA Floridi
Oct 11, 1982·Biochimica Et Biophysica Acta·J A Martínez-IzquierdoR Parrilla
Jun 1, 1985·Experimental and Molecular Pathology·A FloridiA Caputo
Jan 1, 1985·Archives of Biochemistry and Biophysics·K RavidY Avi-Dor

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