Stimulation of protein synthesis in human neutrophils by gamma-interferon

Biochemical Pharmacology
J M HumphreysS W Edwards

Abstract

Treatment of human, peripheral blood neutrophils with gamma-interferon both "primed" their ability to generate reactive oxidants and increased their rate of protein synthesis. This increased rate of protein synthesis was greatest 60 min after the addition of 100 U/ml gamma-interferon and was not due to an increased intracellular pool of radiolabelled amino acid. Analysis of the newly-synthesized polypeptides by two-dimensional polyacrylamide gel electrophoresis (PAGE) revealed two classes of proteins which were regulated by this agent. The first of these represented proteins whose rate of labelling increased very little (1-2-fold) whereas the rate of biosynthesis of a second group of proteins increased more markedly (10-20-fold). We propose that these newly-synthesized, gamma-interferon regulated proteins play an important role in the function of these cells during an acute inflammatory response.

References

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Citations

Apr 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·R E Stringer, S W Edwards
May 1, 1993·Annals of the Rheumatic Diseases·F WatsonS W Edwards
Aug 23, 2005·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Andrew CrossSteven W Edwards
Apr 17, 2013·Proteomics. Clinical Applications·Jian-Ying ZhouUNKNOWN Inflammation and the Host Response to Injury Large Scale Collaborative Research Program
Jun 15, 2017·Frontiers in Cellular and Infection Microbiology·Irina MiraldaKenneth R McLeish
Mar 1, 1994·FEMS Immunology and Medical Microbiology·J A QuayleS W Edwards

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