PMID: 9539809May 16, 1998Paper

Stimulation of renin secretion by nitric oxide is mediated by phosphodiesterase 3

Proceedings of the National Academy of Sciences of the United States of America
A KurtzC Wagner

Abstract

This study aimed to characterize the cellular pathways along which nitric oxide (NO) stimulates renin secretion from the kidney. Using the isolated perfused rat kidney model we found that renin secretion stimulated 4- to 8-fold by low perfusion pressure (40 mmHg), by macula densa inhibition (100 micromol/liter of bumetanide), and by adenylate cyclase activation (3 nmol/liter of isoproterenol) was markedly attenuated by the NO synthase inhibitor nitro-L-arginine methyl ester (L-Name) (1 mM) and that the inhibition by L-Name was compensated by the NO-donor sodium nitroprusside (SNP) (10 micromol/liter). Similarly, inhibition of cAMP degradation by blockade of phosphodiesterase 1 (PDE-1) (20 micromol/liter of 8-methoxymethyl-1-methyl-3-(2-methylpropyl)xanthine) or of PDE-4 (20 micromol/liter of rolipram) caused a 3- to 4-fold stimulation of renin secretion that was attenuated by L-Name and that was even overcompensated by sodium nitroprusside. Inhibition of PDE-3 by 20 micromol/liter of milrinone or by 200 nmol/liter of trequinsin caused a 5- to 6-fold stimulation of renin secretion that was slightly enhanced by NO synthase inhibition and moderately attenuated by NO donation. Because PDE-3 is a cGMP-inhibited cAMP-PDE the role of ...Continue Reading

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Citations

Apr 28, 2012·Pflügers Archiv : European journal of physiology·Douglas K Atchison, William H Beierwaltes
Jun 6, 2012·Pflügers Archiv : European journal of physiology·Jurgen Schnermann, Josephine P Briggs
Jun 27, 2012·Pflügers Archiv : European journal of physiology·Ulla G FriisBoye L Jensen
Sep 12, 2002·European Journal of Pharmacology·Mohammad-Reza ZarrindastTaraneh Bahreini
Oct 12, 2000·Free Radical Biology & Medicine·M Belén HerreroC Gagnon
Dec 26, 2001·Trends in Endocrinology and Metabolism : TEM·Celine MehatsMarco Conti
Aug 22, 2000·Acta Physiologica Scandinavica·A E Persson, S Bachmann
Jun 22, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ulla G FriisOle Skøtt
Jul 31, 2009·American Journal of Physiology. Renal Physiology·William H Beierwaltes
Oct 28, 1998·The Journal of Clinical Investigation·C WagnerA Kurtz
Apr 17, 2010·Journal of the American Society of Nephrology : JASN·Limeng ChenJosephine P Briggs
May 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·J G HoenderopR J Bindels
Jul 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·K TamuraV J Dzau
Oct 13, 2010·Annual Review of Physiology·Armin Kurtz
Nov 20, 2002·Expert Opinion on Investigational Drugs·Matthew A Movsesian, Rami Alharethi
Jul 31, 2004·Acta Physiologica Scandinavica·F Schweda, A Kurtz
Sep 9, 2004·Molecular and Cellular Endocrinology·Kouichi TamuraVictor J Dzau
Apr 16, 2016·Current Hypertension Reports·Evanthia Mergia, Johannes Stegbauer
Jan 3, 2018·Pflügers Archiv : European journal of physiology·Sarah DünnesAndreas Friebe
Mar 11, 2004·American Journal of Physiology. Renal Physiology·Alex PaliegeTianxin Yang
Jul 24, 2010·American Journal of Hypertension·Johan SällströmA Erik G Persson
Dec 24, 2005·Physiological Reviews·F HofmannJ Schlossmann
Aug 3, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Helmy M SiragyRobert M Carey
Feb 1, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Elzbieta Kompanowska-JezierskaPeter Bie
Jan 13, 2012·American Journal of Hypertension·Armin Kurtz
Sep 18, 2002·The Journal of Pharmacology and Experimental Therapeutics·Thomas E N JonassenNiels V Olsen
Apr 16, 2010·Physiological Reviews·Hayo CastropCharlotte Wagner
Jan 24, 2018·American Journal of Physiology. Renal Physiology·D SteppanA Kurtz
Nov 21, 2019·Biological Chemistry·Franz Hofmann
Oct 12, 2007·Physiology·Frank SchwedaArmin Kurtz
Aug 6, 2019·Frontiers in Pharmacology·Andrea SchrammJens Schlossmann
May 12, 2000·American Journal of Physiology. Renal Physiology·A RoczniakK D Burns
Dec 9, 1998·The American Journal of Physiology·A Kurtz, C Wagner
Feb 2, 2006·American Journal of Physiology. Renal Physiology·William H Beierwaltes

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