Stimulation of replication efficiency of a chromatin template by chromosomal protein HMG-17.

The Journal of Biological Chemistry
B VestnerC Gruss

Abstract

The effect of chromosomal protein HMG-17 on the replication of a chromatin template was studied with minichromosomes containing the SV40 origin of replication. The minichromosomes were assembled from M13 DNA in Xenopus egg extracts in either the absence or presence of HMG-17. Structural data show that HMG-17 was efficiently incorporated into the chromatin and induced an extended chromatin structure. Using an in vitro SV40 replication system, we find that minichromosomes containing HMG-17 replicate with higher efficiency than minichromosomes deficient of HMG-17. The replicational potential of chromatin was enhanced only when HMG-17 was incorporated into the template during, but not after, chromatin assembly. HMG-17 stimulated replication only from a chromatin template, but not from protein-free DNA. Thus, HMG-17 protein enhances the rate of replication of a chromatin template by unfolding the higher order chromatin structure and increasing the accessibility of target sequences to components of the replication machinery.

References

Jan 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·H J VollenweiderT Koller
Feb 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·S Weisbrod, H Weintraub
Dec 1, 1991·Molecular and Cellular Biology·T Krude, R Knippers
Jun 11, 1991·Nucleic Acids Research·M BustinJ Shiloach
Dec 1, 1990·Trends in Genetics : TIG·M Grunstein
Jul 30, 1990·Biochimica Et Biophysica Acta·M BustinD Landsman
Oct 11, 1990·Nucleic Acids Research·G AlmouzniA P Wolffe
Aug 20, 1990·Journal of Molecular Biology·V Graziano, V Ramakrishnan
Jan 1, 1990·The Biochemical Journal·A Csordas
Mar 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M Yamaguchi, M L DePamphilis
Aug 1, 1985·Molecular and Cellular Biology·B W Stillman, Y Gluzman
Oct 1, 1986·Experimental Cell Research·S DruckmannM Bustin
Jan 1, 1980·Cell·S WeisbrodH Weintraub
Dec 1, 1994·Chromosoma·P Loidl
Apr 1, 1995·Trends in Biochemical Sciences·C L Peterson, J W Tamkun
May 1, 1994·Journal of Cellular Biochemistry·J R Davie, M J Hendzel
Apr 1, 1993·Current Opinion in Genetics & Development·J Svaren, W Hörz
Mar 1, 1993·Trends in Biochemical Sciences·J L Workman, A R Buchman
Jun 1, 1996·Molecular and Cellular Biology·G QuintiniR Knippers
Jul 12, 1996·Cell·G Felsenfeld
Apr 1, 1996·Current Opinion in Genetics & Development·J Svaren, W Hörz
Jan 1, 1996·Progress in Nucleic Acid Research and Molecular Biology·C Gruss, R Knippers
Dec 27, 1996·Cell·B R CairnsR D Kornberg

❮ Previous
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Citations

Jan 14, 2003·Journal of Peptide Science : an Official Publication of the European Peptide Society·Vassiliki A Boumba, Konstantin Seferiadis
Jul 7, 2001·Trends in Biochemical Sciences·M Bustin
Dec 20, 2002·Journal of Structural Biology·Susan A GerbiJohn M Waggener
Mar 1, 2013·Journal of the Royal Society, Interface·Anna A KalashnikovaJeffrey C Hansen
Mar 30, 2000·Protein Science : a Publication of the Protein Society·D F LouieN G Ahn
Dec 22, 2010·Molecular and Cellular Biology·Suresh CuddapahKeji Zhao
Apr 15, 2004·Molecular and Cellular Biology·Katherine L WestMichael Bustin
Aug 5, 2003·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Frédéric CatezMichael Bustin
Mar 15, 2002·Current Opinion in Genetics & Development·Susan A Gerbi, Anja Katrin Bielinsky
Jun 7, 2014·Journal of Molecular Biology·Owen K Smith, Mirit I Aladjem
Jan 25, 2002·International Journal of Cancer. Journal International Du Cancer·Hardi LührsThomas Menzel
Jun 1, 2007·Birth Defects Research. Part C, Embryo Today : Reviews·Elizabeth Cho, Wan-Ju Li
Oct 13, 2011·Cell Biology International·Kasem KulkeawDaisuke Sugiyama
Nov 4, 2009·Journal of Cellular Biochemistry·Toshihiro KurahashiMichael Bustin
Mar 21, 2003·Biochemical and Biophysical Research Communications·Hidetaka SeoHiromu Murofushi
Oct 31, 2001·Differentiation; Research in Biological Diversity·S Lehtonen, E Lehtonen
Oct 14, 2014·The Prostate·Boxing SuLiqun Zhou
Dec 14, 2011·The Biochemical Journal·Gráinne BarkessKatherine L West
Jun 9, 1999·Current Biology : CB·T Krude
Oct 5, 2014·Molecular Biology and Evolution·Rodrigo González-RomeroJuan Ausió
Oct 6, 2005·Journal of Leukocyte Biology·Yun FengBoyao Wang
Dec 18, 1998·The Journal of Biological Chemistry·L HalmerC Gruss
Oct 4, 2017·Nucleic Acids Research·Kevin J MurphyJeffrey J Hayes
Oct 28, 2004·Biochemical Society Transactions·K L West
Sep 4, 2021·Genesis : the Journal of Genetics and Development·Chibuike Ihewulezi, Jean-Pierre Saint-Jeannet

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