Stimulation of suicidal erythrocyte death by amantadine

European Journal of Pharmacology
Michael FöllerFlorian Lang

Abstract

Amantadine is an effective drug for treatment of both, Parkinson's disease and viral infections. Side effects of amantadine include anemia, which may limit its therapeutic use. The cause of amantatine induced anemia is ill defined. At least in theory, the anemia could partially result from suicidal erythrocyte death or eryptosis, which accelerates the clearance of circulating erythrocytes. Eryptosis is characterized by cell shrinkage and cell membrane scrambling leading to phosphatidylserine exposure at the cell surface. Triggers of erythrocyte membrane scrambling include an increase of cytosolic Ca2+ concentration ([Ca2+]i) resulting from activation of Ca2+-permeable cation channels. The present study has been performed to test for an effect of amantadine on eryptosis. Erythrocytes from healthy volunteers were exposed to amantadine and annexin V binding (disclosing phosphatidylserine exposure), forward scatter (reflecting cell volume), and Fluo3-dependent fluorescence (reflecting [Ca2+]i) were determined by flow cytometry. Exposure of erythrocytes to amantadine (> or =0.2 microg/ml) increased [Ca2+]i and triggered annexin V binding, and increased forward scatter. The effect on annexin V binding was virtually abolished in the a...Continue Reading

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Citations

Mar 15, 2008·Inflammatory Bowel Diseases·Corinna GeigerFlorian Lang
Jul 19, 2008·Archives of Toxicology·Hasan MahmudFlorian Lang
Feb 3, 2009·Annals of Hematology·Sergios GatidisFlorian Lang
Jan 12, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Shefalee K BhavsarFlorian Lang
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Mar 27, 2010·Nutrition·Hasan MahmudFlorian Lang
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Aug 12, 2009·Acta Tropica·Paulo Renato Rivas TotinoMaria de Fátima Ferreira-da-Cruz
Apr 11, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Syed M QadriFlorian Lang
May 5, 2009·Life Sciences·Syed M QadriFlorian Lang
May 24, 2008·Toxicology·Hasan MahmudFlorian Lang
Apr 29, 2009·European Journal of Clinical Investigation·M FöllerF Lang
May 16, 2009·Journal of Applied Toxicology : JAT·Mentor SopjaniFlorian Lang
Aug 23, 2008·IUBMB Life·Michael FöllerFlorian Lang
Oct 22, 2008·Journal of Applied Toxicology : JAT·Tan Thanh NguyenFlorian Lang
Mar 31, 2015·BioMed Research International·Elisabeth Lang, Florian Lang
Mar 8, 2018·Journal of Neural Transmission·Santiago Perez-Lloret, Olivier Rascol
Apr 30, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Michael FöllerFlorian Lang
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Mar 9, 2018·BioMed Research International·Lisa Repsold, Anna Margaretha Joubert
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Jan 12, 2010·Journal of Agricultural and Food Chemistry·Matthias EberhardFlorian Lang

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