Stimulation of the Angiotensin II AT2 Receptor is Anti-inflammatory in Human Lipopolysaccharide-Activated Monocytic Cells

Inflammation
Mario MenkClaudia D Spies

Abstract

Recently, AT2 receptors have been discovered on the surface of human immunocompetent cells such as monocytes. Data on regulative properties of this receptor on the cellular immune response are poor. We hypothesized that direct stimulation of the AT2 receptor mediates anti-inflammatory responses in these cells. Human monocytic THP-1 and U937 cells were stimulated with lipopolysaccharide (LPS) and the selective AT2 receptor agonist Compound 21 (C21). Expression of pro- and anti-inflammatory cytokines IL-6, IL-10, tumor necrosis factor-α (TNFα), and IL-1β were analyzed on both the transcriptional and the translational level over course of time. Treatment with C21 attenuated the expression of TNFα, IL-6, and IL-10 after LPS challenge in both cell lines in a time- and dose-dependent manner. We conclude that selective AT2 receptor stimulation acts anti-inflammatory in human monocytes. Modulation of cytokine response by AT2 receptor activation might be a beneficial and novel treatment concept in inflammatory conditions.

References

May 1, 1992·Hypertension·R J JohnsonS M Schwartz
Nov 15, 2001·The Journal of Biological Chemistry·A L AlbistonS Y Chai
Jan 7, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Karen A NahmodJorge R Geffner
Apr 5, 2003·The International Journal of Biochemistry & Cell Biology·Yusuke SuzukiJesus Egido
Nov 13, 2004·Journal of Medicinal Chemistry·Yiqian WanMathias Alterman
Jan 25, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jun LiThomas Unger
May 6, 2006·Journal of the American Society of Nephrology : JASN·Gunter WolfUlrich O Wenzel
Apr 17, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Michael Bader, Detlev Ganten
May 23, 2008·American Journal of Physiology. Renal Physiology·Steven D CrowleyThomas M Coffman
Oct 29, 2009·Journal of the Renin-angiotensin-aldosterone System : JRAAS·U Muscha SteckelingsThomas Unger
Dec 21, 2010·Current Opinion in Pharmacology·U Muscha SteckelingsThomas Unger
Feb 4, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Peter M AbadirHelmy M Siragy
Mar 4, 2011·American Journal of Physiology. Renal Physiology·Li-Jun MaAgnes B Fogo
Oct 8, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Suguru YamamotoValentina Kon
Jan 18, 2012·Journal of Medicinal Chemistry·A M S MurugaiahMathias Alterman
Oct 30, 2012·Acta Pharmacologica Sinica·En-tong YiCheng-hong Yin
Nov 24, 2012·Neurobiology of Disease·Pawel NamsolleckU Muscha Steckelings
Jan 22, 2013·Arthritis and Rheumatism·Wioleta MarutFrédéric Batteux
Sep 3, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Naimeh RafatianStewart C Whitman
Feb 28, 2014·American Journal of Hypertension·Li-Juan MinMasatsugu Horiuchi
Sep 12, 2014·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Isha DhandeTahir Hussain
Oct 21, 2014·Clinical Science·Daniel VillelaU Muscha Steckelings

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Citations

Jun 3, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Carlos M Ferrario, Adam E Mullick
Jun 14, 2017·Medicinal Research Reviews·Mathias HallbergAnders Hallberg
Jul 19, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rafael FrancoGemma Navarro
Jan 16, 2020·Current Pharmaceutical Design·Sanket N PatelTahir Hussain
Nov 20, 2020·Clinical Science·U Muscha Steckelings, Colin Sumners

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