PMID: 9171956Jun 1, 1997Paper

Stimulation of the gastric sodium monitor reduces hepatic angiotensin-converting enzyme activity

Clinical and Experimental Pharmacology & Physiology
K A Duggan, V Z Ye

Abstract

1. The natriuresis engendered by stimulation of the gastric sodium monitor is mediated in part by a decrease in the circulating concentration of angiotensin II (AngII). This decrease is due to decrease in synthesis rather than to an increase in metabolism. We investigated the role of changes in plasma and hepatic angiotensin-converting enzyme (ACE) activity in this decrease in AngII synthesis. 2. Male Sprague-Dawley rats were equilibrated on a low-sodium diet for 7 days. On the day of experiment, rats were anaesthetized and received either a sodium load of 1.5 mmol/kg as 3 mol/L saline or an equivalent volume of an iso-osmotic urea solution by direct gastric puncture. Blood was sampled and livers were harvested at 0 and 30 min after sodium or urea administration. Angiotensin-converting enzyme was measured in serum and tissue homogenates by generation of histidyl-leucine. 3. In the liver, ACE activity decreased from control after both sodium (P < 0.005) and urea (P < 0.025) administration. The decrease was greater in the group that received saline compared with rats that received urea (P < 0.05). Serum ACE decreased in response to urea (P < 0.025) but not sodium administration. 4. We conclude that stimulation of the gastric sodi...Continue Reading

References

Aug 1, 1976·American Journal of Clinical Pathology·J Friedland, E Silverstein

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Citations

Aug 20, 2011·Journal of the American Society of Nephrology : JASN·Stine Falsig PedersenElse K Hoffmann

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