Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects

The Journal of Clinical Endocrinology and Metabolism
I M ChapmanM O Thorner

Abstract

Aging is associated with declining activity of the GH axis, possibly contributing to adverse body composition changes and increased incidence of cardiovascular disease. The stimulatory effects on the GH-insulin-like growth factor I (IGF-I) axis of orally administered MK-677, a GH-releasing peptide mimetic, were investigated. Thirty-two healthy subjects (15 women and 17 men, aged 64-81 yr) were enrolled in a randomized, double blind, placebo-controlled trial. They received placebo or 2, 10, or 25 mg MK-677, orally, once daily for 2 separate study periods of 14 and 28 days. At baseline and on day 14 of each study period, blood was collected every 20 min for 24 h to measure GH, PRL, and cortisol. Attributes of pulsatile GH release were assessed by 3 independent algorithms. MK-677 administration for 2 weeks increased GH concentrations in a dose-dependent manner, with 25 mg/day increasing mean 24-h GH concentration 97 +/- 23% (mean +/- SE; P < 0.05 vs. baseline). This increase was due to an enhancement of preexisting pulsatile GH secretion. GH pulse height and interpulse nadir concentrations increased significantly without significant changes in the number of pulses. With 25 mg/day MK-677 treatment, mean serum IGF-I concentrations i...Continue Reading

Citations

Apr 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Yuxiang SunRoy G Smith
Oct 31, 2003·Molecular and Cellular Biology·Yuxiang SunRoy G Smith
Aug 12, 2010·International Journal of Peptides·Susana Sangiao-Alvarellos, Fernando Cordido
Aug 28, 2010·International Journal of Peptides·Johannes D Veldhuis, Cyril Y Bowers
Mar 13, 2008·The Journal of Clinical Endocrinology and Metabolism·Ralf NassMichael O Thorner
Nov 10, 2005·Journal of Endocrinological Investigation·M GolaA Giustina
May 13, 2009·Nature Reviews. Gastroenterology & Hepatology·Michael CamilleriSuwebatu T Odunsi
May 18, 2004·Wiener klinische Wochenschrift·Adele SchmidtAnton Luger
Oct 19, 2006·World Journal of Urology·Stefan UckertChristian G Stief
Nov 18, 2006·Mechanisms of Ageing and Development·Koji ToshinaiMasamitsu Nakazato
Sep 30, 2009·Journal of Peptide Science : an Official Publication of the European Peptide Society·Constance CholletAnnette G Beck-Sickinger
Mar 9, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Akio InuiMineko Fujimiya
Aug 24, 2017·American Journal of Men's Health·John T SigalosLarry I Lipshultz
Aug 9, 2007·American Journal of Physiology. Endocrinology and Metabolism·Miriam García-San FrutosFranco Sánchez-Franco
Feb 13, 2020·Endocrinology·Morten Adler Hedegaard, Birgitte Holst
Nov 7, 2003·The Journal of Clinical Endocrinology and Metabolism·F TassoneM Maccario
Sep 9, 2006·The Journal of Clinical Endocrinology and Metabolism·Jens Otto Lunde Jørgensen
Mar 29, 2008·Endocrinology·Hiroyuki AriyasuTakashi Akamizu
Jun 8, 2004·Endocrine Reviews·Aart J van der LelyEzio Ghigo
Apr 21, 1999·Clinical Endocrinology·E ArvatE Ghigo
Apr 18, 2003·Clinical Endocrinology·J SvenssonUNKNOWN NN703 Clinical Research Group

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.