PMID: 9124Sep 1, 1976

Stimulation of the peripheral chemoreceptors with sodium bicarbonate

British Journal of Anaesthesia
J G WhitwamK Lewin


The i.v. administration of sodium bicarbonate was found to cause an increase in arterial pH, followed by an increase in PaCO2. This caused a large increase in lung ventilation in in PaO2. Oxygen administration in human subjects, and anatomical denervation of the chemoreceptors in dogs, caused a substantial delay in the ventilatory responses to sodium bicarbonate. It was concluded that the i.v. administration of sodium bicarbonate provides a method of testing the presence of peripheral chemoreflexes which has the advantage of being independent of alveolar ventilation.


Feb 1, 1981·Bulletin of Environmental Contamination and Toxicology·D Liu
Dec 1, 1982·Bulletin of Environmental Contamination and Toxicology·V Drobníková, J Bacílek
Jun 16, 2001·Journal of Applied Physiology·J R RodmanC A Smith

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