Stimulation of the ventral subiculum of the hippocampus evokes glutamate receptor-mediated changes in dopamine efflux in the rat nucleus accumbens

The European Journal of Neuroscience
C D BlahaAnthony G Phillips

Abstract

The effects of electrical stimulation of the ventral subiculum/CA1 region of the hippocampus on changes in dopamine oxidation current (corresponding to dopamine efflux) in the nucleus accumbens were examined using in vivo chronoamperometry with stearate-graphite paste electrodes in urethane-anaesthetized rats. Burst-patterned monophasic pulses (10-100 Hz/burst delivered at 0.8-4 Hz) evoked a three-component change in dopamine efflux in the nucleus accumbens with an initial transient increase in the dopamine signal above baseline, followed by an immediate decrease below baseline, and thereafter by a prolonged increase in the dopamine signal above baseline. 6-Hydroxydopamine lesions of the mesoaccumbens dopamine pathway or transection of the fimbria-fornix blocked all of the evoked changes in the dopamine signal. Both the first and third components of enhanced dopamine efflux were blocked by microinfusion into the nucleus accumbens of the ionotropic glutamate receptor antagonists (+/-)-2-amino-5-phosphonopentanoic acid, 6,7-dinitroquinoxaline-2,3-dione and kynurenate. Burst stimulation-evoked decreases in the dopamine signal were abolished following microinfusions into the nucleus accumbens of the metabotropic glutamate receptor ...Continue Reading

References

Oct 23, 1990·European Journal of Pharmacology·A ImperatoL Angelucci
Jan 15, 1990·Biological Psychiatry·P C Bickford-WimerR Freedman
Jan 1, 1986·Progress in Neurobiology·B H Bland
Dec 1, 1985·Journal of Neurophysiology·J F DeFranceR B Chronister
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Oct 1, 1983·Brain Research·G BuzsákiC H Vanderwolf
Jan 1, 1981·Experimental Brain Research·S E Fox, J B Ranck
Jun 1, 1995·Current Opinion in Neurobiology·J P Pin, J Bockaert
Jan 1, 1995·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·T H Swanson
Jan 1, 1993·Experimental Brain Research·J S Taube
Mar 1, 1994·Epilepsy Research·P A Schwartzkroin
Jan 1, 1993·Schizophrenia Bulletin·B Bogerts
Jul 1, 1993·Journal of Neurophysiology·M Stewart, R K Wong
Jan 1, 1984·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·D Chatterjee, P K Sarkar

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Citations

Jan 13, 2004·Brain Research·Jingyi Ma, L Stan Leung
May 17, 2005·Neuroscience and Biobehavioral Reviews·Alasdair M Barr, Athina Markou
Jul 25, 1998·Pharmacology, Biochemistry, and Behavior·D M Brenner, M E Bardgett
Sep 7, 2000·Neuroscience and Biobehavioral Reviews·L S LeungR S McLachlan
Mar 17, 2000·Brain Research. Brain Research Reviews·A A Grace
Sep 10, 2003·Progress in Neurobiology·Tobias Bast, Joram Feldon
Aug 27, 1999·Progress in Neurobiology·M Koch
Dec 24, 2003·Drug Discovery Today·John F CryanAthina Markou
Mar 25, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Francisca F Meyer, Alain Louilot
Feb 4, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Teodoro ZornozaLuis Granero
Aug 27, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Pia Bäckström, Petri Hyytiä
Dec 2, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Daniel J Lodge, Anthony A Grace
Jul 23, 1999·Annals of the New York Academy of Sciences·B J EverittT W Robbins
Jul 23, 1999·Annals of the New York Academy of Sciences·C L Todd, A A Grace
Jul 23, 1999·Annals of the New York Academy of Sciences·K L Sweet, D B Neill
Mar 17, 2012·Journal of Neurophysiology·Yuchun ZhangJohn E Lisman
Apr 25, 2012·Journal of Cognitive Neuroscience·Sasha M WolosinAlison R Preston
Sep 26, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Pauline Belujon, Anthony A Grace
Jan 8, 2016·Brain Structure & Function·Lesley A McCollumRosalinda C Roberts

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