Stimulation of toll-like receptor 2 in mononuclear cells from HIV-infected patients induces chemokine responses: possible pathogenic consequences

Clinical and Experimental Immunology
L HeggelundS S Frøland

Abstract

Toll-like receptor 2 (TLR2) stimulation in monocytes may contribute to enhanced inflammation and viral replication in HIV infection. In the present study we examined if TLR2 stimulation could modulate chemokine responses in peripheral blood mononuclear cells (PBMC) from HIV-infected patients and healthy controls. Our main findings were, with similar qualitative patterns in both healthy controls and HIV-infected patients: (1) TLR2 stimulation induced up-regulation of several chemokines at the mRNA level as well as increased protein levels of macrophage inflammatory protein (MIP)-1alpha, interleukin (IL)-8 and regulated on activation, normal T cell expressed and secreted (RANTES); (2) TLR2 stimulation induced enhanced protein expression of CCR5 (a receptor for MIP-1alpha and RANTES) on monocytes; (3) In vitro stimulation with RANTES induced release of MIP-1alpha, MCP-1, IL-8 and interferon-gamma from PBMC. While increased levels of beta-chemokines possibly have antiviral effects, TLR2 stimulation may also promote a chemokine-driven inflammatory loop, potentially contributing to the immunopathogenesis of HIV infection.

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Citations

Jan 11, 2008·AIDS Research and Human Retroviruses·Sushila K NordoneGregg A Dean
Jan 28, 2012·AIDS Research and Human Retroviruses·Juan C HernándezSilvio Urcuqui-Inchima
Jun 15, 2013·AIDS Research and Human Retroviruses·Basile SieweAlan Landay
Jul 31, 2013·Immunobiology·Sabina VictoriaDumith Chequer Bou-Habib
Aug 18, 2016·Frontiers in Immunology·Bethany M HenrickKenneth Lee Rosenthal
Jun 9, 2016·Immunology·Christian BleauLucie Lamontagne
May 29, 2007·International Review of Neurobiology·Behrouz NikbinFatemeh Talebian
Nov 22, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Lena SerghidesKevin C Kain
Aug 27, 2015·Journal of Leukocyte Biology·Gloria DonninelliManuela Del Cornò

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