PMID: 3697715Mar 5, 1986

Stimulation of tryptophan uptake into brain microvessels by D-glutamine

Brain Research
M Gorgievski-HrisohoC Bachmann

Abstract

The uptake of L-tryptophan into isolated porcine microvessels is increased by preincubation with L-glutamine as well as with D-glutamine. This could indicate that gamma-glutamyltranspeptidase is involved in the stimulation of uptake of large neutral amino acids into the brain observed in hyperammonemic conditions.

References

Role of protein dissociation in the transport of acidic amino acids by the Ehrlich ascites tumor cell

Jan 21, 1977·Biochimica Et Biophysica Acta·J Garcia-SanchoH N Christensen

Isolated microvessels: the blood-brain barrier in vitro

Sep 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J T HjelleS Udenfriend

Methionine sulfoximine prevents the accumulation of large neutral amino acids in brain of hyperammonemic rats

Apr 1, 1984·The Journal of Surgical Research·T JonungJ E Fischer

Citations

Glutamine as a pathogenic factor in hepatic encephalopathy

Jul 4, 2001·Journal of Neuroscience Research·J Albrecht, M Dolińska

Characteristics of large neutral amino acid-induced release of preloaded L-glutamine from rat cerebral capillaries in vitro: effects of ammonia, hepatic encephalopathy, and gamma-glutamyl transpeptidase inhibitors

Jun 1, 1992·Journal of Neuroscience Research·W HilgierJ Albrecht

The effect of acute and repeated hyperammonemia on gamma-glutamyl transpeptidase in homogenates and capillaries of various rat brain regions

Aug 1, 1990·Molecular and Chemical Neuropathology·W HilgierF Stastný

Alterations of blood brain barrier function in hyperammonemia: an overview

Aug 30, 2011·Neurotoxicity Research·Marta Skowrońska, J Albrecht

The blood-brain barrier in vitro: the second decade

Dec 1, 1993·Neurochemistry International·F Joó

Endothelial cells of the brain and other organ systems: some similarities and differences

Feb 1, 1996·Progress in Neurobiology·F Joó

Changes in the activity of gamma-glutamyl transpeptidase in brain microvessels, astroglial cells and synaptosomes derived from rats with hepatic encephalopathy

Feb 3, 1988·Neuroscience Letters·F StastnýV Lisý

Ammonia toxicity to the brain and creatine

Mar 31, 2004·Molecular Genetics and Metabolism·C BachmannHugues Henry

Mechanisms of hyperammonemia

Sep 21, 2002·Clinical Chemistry and Laboratory Medicine : CCLM·C Bachmann

Changes in the activity of gamma-glutamyl transpeptidase induced by kainic acid and surgical lesions of the hippocampal formation in young rats

Oct 11, 1988·Brain Research·F StastnýV Lisý

Hyperammonemia and intracerebral transfer of tryptophan

Mar 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J P Colombo, C Bachmann

Serotonin- and catecholamine-related substances in the brain of ornithine transcarbamylase-deficient Sparse-fur mice in the hyperammonemic state: comparison of two procedures for obtaining brain extract, decapitation and microwave irradiation

Dec 1, 1989·Biochemical Medicine and Metabolic Biology·I InoueT Fukuda

Enantioseparation of N-acetyl-glutamine enantiomers by LC-MS/MS and its application to a plasma protein binding study

Apr 25, 2019·Biomedical Chromatography : BMC·Lei GaoYuan Tian

Related Concepts

Ammonia
Blood - Brain Barrier Anatomy
Brain
D-Glutamine
Microcirculation
Molecular Stereochemistry
PMS-Tryptophan

Related Feeds

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Related Papers

Mechanisms of hyperammonemia

(opens in new tab)
Clinical Chemistry and Laboratory Medicine : CCLM
C Bachmann

gamma-Glutamylglutamine identified in plasma and cerebrospinal fluid from hyperammonaemic patients

(opens in new tab)
Clinica Chimica Acta; International Journal of Clinical Chemistry
J W HammondB Wilcken
ContactHelpTerms Privacy Cookies Blog
© 2021 Meta ULC. All rights reserved