Stimulation of tubular secretion of creatinine in health and in conditions associated with reduced nephron mass. Evidence for a tubular functional reserve

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
J Herrera, B Rodríguez-Iturbe

Abstract

The increment in glomerular filtration rate (GFR) after a protein load has been taken to reflect the renal reserve capacity; however, this response is preserved in end-stage kidney disease. Tubular secretion of creatinine is increased in relation to the GFR in renal failure, but little is known about the tubular functional response to stimulation despite the fact that tubulointerstitial lesions are always pre-eminent in chronic renal damage. Therefore we decided to compare the urinary creatinine excretion (UcrV) and tubular secretion of creatinine (TScr) induced by a test meat meal in normal individuals and in individuals with reduced nephron mass. We studied 12 normal subjects, seven healthy uninephrectomized (kidney donors) and eight patients with chronic renal disease (serum creatinine ranging from 212.2 to 486 micromol/l). They had been on a standard diet for 5 days before the studies. The test meal provided 80 g of animal protein. Three baseline and four stimulated (post-meal) 30-min simultaneous inulin and creatinine clearances were carried out. We found that normals increased more than twice the UcrV (post-meal=329.5 +/-SEM 13.1 nmol/min/kg) and 3.4 times the TScr (114.4+/-12.7 nmol/min/kg) after the test meal. In contra...Continue Reading

Citations

Jul 26, 2006·European Journal of Nuclear Medicine and Molecular Imaging·A PiepszH Ham
Apr 29, 2010·Current Diabetes Reports·Kunal ChaudharyAdam Whaley-Connell
Feb 6, 2008·Nature Clinical Practice. Nephrology·Richard Solomon, Alan Segal
Mar 7, 2001·Kidney International·B Rodríguez-IturbeR Mañalich
Apr 15, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sri G YarlagaddaChirag R Parikh
Mar 5, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Steef J SinkelerGerjan Navis
May 15, 2007·Nephrology·Ricardo M HeguilénAmelia R Bernasconi
Mar 4, 2014·BioMed Research International·Richard Solomon
Apr 21, 2012·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Jonatan Barrera-Chimal, Norma A Bobadilla
Oct 6, 2011·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·W Stephen Waring, Alasdair Moonie
Sep 10, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Michael E WasungMagdalena Madero
May 30, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Edwin M SpithovenRon T Gansevoort
Apr 10, 2012·Néphrologie & thérapeutique·Benyounès RamdaniGhizlane Medkouri
Mar 2, 2012·Clinical and Translational Science·Abolfazl ZarjouAnupam Agarwal
Jul 22, 2014·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Richard Sinert, Ethan Brandler
Jul 17, 2015·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Fatima I Al-Beladi
Jun 10, 2016·Mathematical Medicine and Biology : a Journal of the IMA·Ioannis SgouralisAnita T Layton
Nov 9, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Rakesh Malhotra, Edward D Siew
Feb 28, 2017·Nature Reviews. Nephrology·Lakhmir S ChawlaUNKNOWN Acute Disease Quality Initiative Workgroup 16.
Mar 25, 2016·World Journal of Transplantation·Patricia WiesenPierre Damas
Feb 12, 2019·Annual Review of Physiology·William R Zhang, Chirag R Parikh
Feb 8, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Steven G Coca, Chirag R Parikh
Mar 28, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·José HerreraBernardo Rodríguez-Iturbe
Jul 14, 2000·Physiological Reviews·M Wyss, R Kaddurah-Daouk
Aug 24, 2019·Expert Review of Proteomics·Justyna SiwyPetra Zürbig
Jun 15, 2012·Insights Into Imaging·Richard W KatzbergChin-Shang Li
Feb 22, 2001·The American Journal of Medicine·R TakahiraA Hishida

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.