PMID: 9539963Apr 16, 1998Paper

Stimulation of uncoupling protein synthesis in white adipose tissue of mice treated with the beta 3-adrenergic agonist CGP-12177

Cellular and Molecular Life Sciences : CMLS
Catalina PicóAndreu Palou

Abstract

The effects of chronic treatment with the beta 3-adrenergic receptor agonist CGP-12177 on uncoupling protein (UCP) synthesis in interscapular brown adipose tissue (IBAT), various white fat depots and skeletal muscle have been examined in the mouse (daily injection for 15 days at a dose of 0.5 mg/kg). The treatment increased the IBAT UCP content and led to the expression of UCP in inguinal white adipose tissue. The increase in IBAT UCP content took place in the absence of tissue hypertrophy, and despite the increase in total body UCP content, no changes in body weight were observed after the treatment. The results confirm that ectopic expression of UCP in non-BAT tissues can be induced after chronic adrenergic stimulation.

Citations

Dec 29, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·P J ScarpaceN Tümer
Jul 24, 2015·Molecular Nutrition & Food Research·Jon MerlinDana S Hutchinson
Jan 13, 2015·Frontiers of Medicine·Shuwen QianQiqun Tang
Jul 4, 2013·International Journal of Molecular Sciences·Koji Mikami, Masashi Hosokawa
May 11, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·P OliverA Palou
Feb 26, 2019·British Journal of Pharmacology·Bronwyn A EvansDana S Hutchinson
Sep 13, 2015·Biochemical and Biophysical Research Communications·Shan WangZifan Lu

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