Stimulation of vagal pulmonary C fibers by inhaled wood smoke in rats

Journal of Applied Physiology
C J Lai, Y R Kou

Abstract

This study investigated the stimulation of vagal pulmonary C fibers (PCs) by wood smoke. We recorded impulses from PCs in 58 anesthetized, open-chest, and artificially ventilated rats and delivered 6 ml of wood smoke into the lungs. Within 1 or 2 s after the smoke delivery, an intense and nonphasic burst of discharge [delta = +7.4 +/- 0.7 (SE) impulses/s, n = 68] was evoked in 60 of the 68 PCs studied and lasted for 4-8 s. This immediate stimulation was usually followed by a delayed and more sustained increase in C-fiber activity (delta = +2.0 +/- 0.4 impulses/s). The overall stimulation was not influenced by removal of smoke particulates (n = 15) or by pretreatment with vehicle (n = 8) for dimethylthiourea (DMTU; a hydroxyl radical scavenger) or indomethacin (Indo; a cyclooxygenase inhibitor). The immediate-phase stimulation was not affected by pretreatment with Indo (n = 8) but was largely attenuated by pretreatment with DMTU (n = 12) or by a combined treatment with DMTU and Indo (DMTU + Indo; n = 8). Conversely, the delayed-phase stimulation was partially suppressed either by DMTU or by Indo but was totally abolished by DMTU + Indo. These results suggest that 1) the stimulation of PCs is linked to the gas phase of wood smoke...Continue Reading

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Citations

Nov 12, 2005·Journal of Occupational and Environmental Medicine·Kai-Jen ChuangTa-Chen Su
May 31, 2011·Experimental Physiology·Shuxin LinJerry Yu
Feb 27, 2016·Inhalation Toxicology·Olorunfemi AdetonaLuke P Naeher
Jun 27, 2018·Journal of Neurotrauma·Kun-Ze Lee, Ke-Jun Xu
Feb 8, 2003·Environmental Health Perspectives·Tsun-Jen ChengChang-Chuan Chan
Jun 15, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Simon S WongMark L Witten
Jul 9, 2004·Environmental Health Perspectives·Chang-Chuan ChanLian-Yu Lin
Dec 7, 2005·Environmental Health Perspectives·Kai-Jen ChuangLian-Yu Lin
Jun 7, 2008·Journal of Applied Physiology·Y L Kuo, C J Lai
Oct 19, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mei-Ya ShenChing Jung Lai
Jan 1, 2010·Inhalation Toxicology·Christopher T Migliaccio, Joe L Mauderly
Jun 8, 2001·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Simon C. GandeviaJane E. Butler
Nov 28, 2006·Inhalation Toxicology·Luke P NaeherKirk R Smith
Dec 22, 2005·Journal of Occupational Health·Chuen-Chau ChangTsun-Jen Cheng
Jul 23, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Stefan BarathAnders Blomberg
Jan 11, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Elisa GhelfiBeatriz Gonzalez-Flecha
May 24, 2006·Inhalation Toxicology·M D ReedS K Seilkop
Mar 22, 2002·Clinical and Experimental Pharmacology & Physiology·S C GandeviaJ L Taylor
Apr 17, 2018·Chemical Research in Toxicology·Cassandra E Deering-RiceChristopher A Reilly

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