PMID: 2120515Oct 1, 1990Paper

Stimulation of wound bursting strength during protein malnutrition

The Journal of Surgical Research
Y ZaizenJ B Atkinson

Abstract

Nutrition is one of the most important factors affecting wound healing. Patients who have significant protein malnutrition and require emergency surgery are frequently encountered. Conventional nutritional preparation for surgery, with intravenous hyperalimentation, requires 10 to 14 days to demonstrate advantageous reversal of catabolism. Growth hormone is known to have an anabolic effect in malnourished animals. The purpose of this investigation was to study the ability of growth hormone, administered from the time of celiotomy, to improve wound strength in protein-malnourished animals and compare its efficacy with preoperative nutritional repletion. Rats were divided into four groups: Group I--normal control rats, group II--malnourished rats, group III--malnourished rats treated with growth hormone for 5 postoperative days, and group IV--malnourished rats refed normal chow for 3 days before operation. Controlled laparotomy wounds were closed with monofilament nylon which was removed at the time wound bursting strength was tested. Bursting strengths at the sixth day postoperative were as follows (means +/- SD): (table; see text) Wound strength of malnourished animals was significantly less than that of controls, (P less than ...Continue Reading

Citations

Aug 6, 1998·The British Journal of Surgery·T KarahasanogluK Alemdaroglu
Jan 1, 1992·Thyroid : Official Journal of the American Thyroid Association·P J HoA Barkan
Jan 1, 1997·APMIS. Supplementum·P H Jørgensen
Jan 24, 2009·JPEN. Journal of Parenteral and Enteral Nutrition·Carolina Gomes GonçalvesAntonio Carlos L Campos
Nov 1, 2007·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Yousheng LiJieshou Li
Jun 1, 1994·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·H H Steenfos

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