Stimulation of wound healing using bioinspired hydrogels with basic fibroblast growth factor (bFGF)

International Journal of Nanomedicine
Xiaoyu ZhangZunyi Wang

Abstract

The objective of this study is to stimulate wound healing using bioinspired hydrogels with basic fibroblast growth factor (bFGF). Inspired by the crosslinking mechanism in algae-based adhesives, hydrogels were fabricated with gum arabic, pectin, and Ca2+. The physical properties of the bioinspired hydrogels were characterized, and the in vitro release of bFGF was investigated. Then, the in vitro scratch assay for wound healing and in vivo wound healing experiment in a full-thickness excision wound model were performed for the bioinspired hydrogels with bFGF. Finally, histological examinations and organ toxicity tests were conducted to investigate the wound healing applications of the bioinspired hydrogels with bFGF. The in vitro and in vivo results showed that the bioinspired hydrogels with bFGF could significantly enhance cell proliferation, wound re-epithelialization, collagen deposition, and contraction without any noticeable toxicity and inflammation compared with the hydrogels without bFGF and commercial wound healing products. These results suggest the potential application of bioinspired hydrogels with bFGF for wound healing.

Citations

Jan 18, 2019·Neurospine·Chin-Chu KoHenrich Cheng
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Methods Mentioned

BETA
atomic
dynamic light scattering
AFM
enzyme-linked immunosorbent assay
ELISA
biopsy

Software Mentioned

PicoPlus AFM

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