Stimulation or lesion of the medial vestibular nucleus increases the number of choline acetyltransferase-positive efferent vestibular neurons in the brainstem

Neuroreport
Yu-Juan ZhouJing Wang

Abstract

The vestibular center of the brainstem contains afferent and efferent vestibular neurons, which play an important role in information perception, processing, and sensory integration. Vestibular efferent neurons (VENs) can receive changes in vestibular afferent information and regulate peripheral vestibular function; however, it remains unclear how VENs change after vestibular afferent information increases or weakens. In this study, we used animal models with altered vestibular afferent information by electrically stimulating or destroying the vestibular medial nucleus (MVe). We confirmed the location of VENs in the brainstem by injecting five adult male Wistar rats in the vestibular region with a retrograde tracer. Following this, the MVe was stimulated electrically for 30 min in 20 naive rats. Rats were anesthetized and euthanized 1, 3, 6, and 12 h after stimulation. The MVe was electrolytically lesioned in another group (n=20); then, the rats were anesthetized and euthanized 1, 3, 5, and 7 days after lesioning. VENs were clearly identified dorsolateral to the genu of the facial nerve (g7) in coronal brainstem sections using choline acetyltransferase (ChAT) staining. The number of ChAT-positive VENs dorsolateral to g7 increas...Continue Reading

References

Oct 1, 1994·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·A IshiyamaP A Wackym
Apr 1, 1993·Physiological Reviews·M Eybalin
Feb 13, 2001·Brain Research·M E ShinderA A Perachio
Jun 16, 2005·Neuroscience Letters·Chuan LiYing-Shing Chan
Sep 1, 2005·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Elizabeth Knyihar-CsillikBertalan Csillik
Jan 20, 2006·Experimental Brain Research·Brent A MettsAdrian A Perachio
Oct 20, 2006·Acta Pharmacologica Sinica·Wei-jia KongPaul van Cauwenberge
May 14, 2008·Journal of the Association for Research in Otolaryngology : JARO·David M LaskerLloyd B Minor
Jul 3, 2009·Journal of Neurophysiology·Richard BoyleStephen M Highstein
Mar 30, 2013·Behavioural Brain Research·C W PereiraF E Olucha-Bordonau
May 8, 2013·NeuroRehabilitation·Sarah Khan, Richard Chang
Nov 2, 2013·Journal of Vestibular Research : Equilibrium & Orientation·Paivi M JordanJ Chris Holt
Apr 10, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C S EricksonA Gosain
Apr 30, 2014·Brain, Behavior and Evolution·Ulrike J SienknechtBernd Fritzsch
Jan 7, 2015·The Journal of Comparative Neurology·Paivi M JordanJoseph C Holt
Feb 27, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·J Chris HoltAnna Lysakowski

❮ Previous
Next ❯

Software Mentioned

Stata
GraphPad Prism
Image J

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.