Stimulatory action of cyclooxygenase inhibitors on hematopoiesis: a review.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Michal HoferDenisa Komůrková

Abstract

The presented review summarizes experimental data obtained with a mouse model when investigating the relationship between inhibition of prostaglandin production and hematopoiesis. While prostaglandin E2 acts in a negative feedback control of myelopoiesis, inhibition of cyclooxygenases, responsible for its production, shifts the feedback to positive control. Based on these relationships, agents inhibiting cyclo-oxygenases, known as non-steroidal anti-inflammatory drugs (NSAIDs), can activate hematopoiesis and be protective or curative under myelosuppressive states. The effectiveness of therapeutic use of NSAIDs in these situations is expressive especially under the selective inhibition of cyclooxygenase-2 (COX-2), when undesirable side effects of cyclooxygenase-1 inhibition, like gastrointestinal damage, are absent. The effects of the clinically approved selective COX-2 inhibitor, meloxicam, were investigated and demonstrated significant hematopoiesis-stimulating and survival-enhancing actions of this drug in sublethally or lethally γ-irradiated mice. These effects were connected with the ability of meloxicam to increase serum levels of the granulocyte colony-stimulating factor. It can be inferred from these findings that select...Continue Reading

References

Nov 1, 1977·International Journal of Dermatology·M E Goldyne
Aug 1, 1993·The Journal of Pharmacy and Pharmacology·A A IzzoF Capasso
Apr 1, 1996·Annals of the Rheumatic Diseases·T MahmudI Bjarnason
Jun 1, 1996·Journal of Clinical Pharmacology·J D McCrackenY Mineyama
Jun 18, 1998·Bioorganic & Medicinal Chemistry·I O DonkorV Kishore
Jan 14, 1999·Carcinogenesis·A P GoldmanR N DuBois
Oct 21, 1999·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·A M AghaH Al-Zuhair
Jan 22, 2000·Arthritis and Rheumatism·L J CroffordL B van de Putte
Jun 22, 2000·International Journal of Cancer. Journal International Du Cancer·H J Hussey, M J Tisdale
Aug 31, 2000·Annual Review of Biochemistry·W L SmithR M Garavito
Feb 8, 2003·Annual Review of Biophysics and Biomolecular Structure·R Michael Garavito, Anne M Mulichak
Oct 8, 2003·Current Pharmaceutical Design·Angel LanasJosep M Piqué
Oct 17, 2003·The Journal of Pharmacology and Experimental Therapeutics·Hideo Kohka TakahashiMasahiro Nishibori
Aug 20, 2004·Pharmacological Reviews·Daniel L SimmonsTimothy Hla
Jul 16, 2005·Journal of Internal Medicine·D Pereg, M Lishner
Aug 6, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yukihiko SugimotoAtsushi Ichikawa
Oct 13, 2005·Experimental Hematology·Francis Hérodin, Michel Drouet
Apr 11, 2008·Experimental Hematology·Francis Hérodin, Michel Drouet
Nov 26, 2009·Radiation Research·W JiaoG D Ledney

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Citations

Sep 3, 2013·Pharmacology & Therapeutics·Christopher N Floyd, Albert Ferro
May 24, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michal HoferMartin Falk
Nov 9, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michal HoferMartin Falk
Nov 5, 2020·Biomedicines·Elena ObradorAlegría Montoro

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