PMID: 6164707Jun 1, 1981Paper

Stimulatory and inhibitory effects of substance P on rat submandibular secretion

Journal of Dental Research
J R Martinez, A M Martinez

Abstract

Intravenous infusions of the undecapeptide substance P caused a moderate but transient secretory response from the rat submandibular gland. The electrolyte composition of the saliva elicited by this peptide was qualitatively similar to that of the secretion induced by parasympathomimetic agents. Substance P inhibited the secretory response to acetylcholine and isoproterenol, but did not modify the binding of specific ligands to glandular autonomic receptors. It is concluded that this naturally occurring peptide plays a role in the physiologic regulation of salivary secretions, which involves both direct stimulatory effects and a modulating action on the effect of autonomic neurotransmitters on the salivary gland cells. The latter may involve similar effects of substance P and the neurotransmitters on a metabolic pathway localized beyond receptor activation.

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Citations

Nov 19, 1985·European Journal of Pharmacology·Z Y FriedmanZ Selinger
Aug 1, 1991·Journal of Pharmacological Methods·L E WagnerJ M Yanni
Sep 9, 2004·Archives of Oral Biology·Paula SchaiquevichRubio Modesto
Jan 1, 1982·Transactions of the Royal Society of Tropical Medicine and Hygiene·A Ferrante
Aug 1, 1984·Journal of Dental Research·N FlemingK W Graham
Dec 1, 1986·Journal of Dental Research·E BobyockW S Chernick
May 1, 1987·Journal of Oral Rehabilitation·K L Messenger, N Barghi
Jan 1, 1990·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·J R Martinez
Feb 1, 1987·Journal of Dental Research·J R Martinez
Dec 1, 1987·The American Journal of Physiology·C DreuxB Rossignol
Jul 15, 1998·Seminars in Arthritis and Rheumatism·H P FischerI J Russell
Nov 1, 1986·Japanese Journal of Pharmacology·Y IwabuchiT Masuhara

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