Stimulatory effect of bone morphogenetic protein-2 on osteoclast-like cell formation and bone-resorbing activity

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
M KanataniK Chihara

Abstract

Although the action of bone morphogenetic protein (BMP) on osteoblast differentiation has been extensively investigated, its effect on osteoclast differentiation remains unknown. In the present study, in vitro effects of BMP-2 on osteoclast-like cell formation and bone resorption were examined. BMP-2 (1-100 ng/ml) significantly stimulated bone resorption by preexistent osteoclast-like cells in mouse bone cell cultures containing stromal cells, whereas it did not affect the bone-resorbing activity of isolated rabbit osteoclast-like cells. When BMP-2 was added to unfractionated bone cells after degeneration of preexistent osteoclast-like cells, BMP-2 dose-dependently stimulated osteoclast-like formation at a minimal effective concentration of 10 pg/ml. BMP-2 also enhanced the osteoclast-like cell formation induced by 1,25-dihydroxyvitamin D3 (1,25(OH)2D3). Moreover, osteoclast-like cells newly formed by BMP-2 from unfractionated bone cells possessed the ability to form pits on dentine slices. Because these results indicated that BMP-2 directly or indirectly stimulated osteoclast differentiation and activity, we next examined the direct effect of BMP-2 on osteoclast precursors in the absence of stromal cells using hemopoietic blas...Continue Reading

References

Jul 31, 1992·Biochemical and Biophysical Research Communications·K TezukaM Kumegawa
Jan 1, 1991·Molecular Endocrinology·R G HammondsA J Mason
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·E A WangP LaPan
Sep 29, 1989·Biochemical and Biophysical Research Communications·Y HakedaM Kumegawa
Jun 1, 1989·Endocrinology·M Noda, J J Camilliere
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C ChenuG D Roodman
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·A H Reddi, C Huggins
Nov 12, 1965·Science·M R Urist
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·T K Sampath, A H Reddi
Feb 1, 1981·Collagen and Related Research·A H Reddi
Jul 1, 1982·Journal of Cellular Physiology·H A KodamaS Kasai
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·A SuzukiN Ueno
Mar 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S E HarrisG R Mundy
Dec 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T SugimotoK Chihara

❮ Previous
Next ❯

Citations

Jan 30, 2010·Injury·Adam L ShimerAlexander R Vaccaro
Aug 23, 2001·Biomaterials·A Bruinink, E Wintermantel
Aug 10, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Xia GuoChung Yiu Jack Cheng
Dec 11, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Dennis M CullinaneEdmund Y S Chao
Jun 11, 2010·Tissue Engineering. Part a·Claudia Di BellaDavide Donati
May 18, 2011·The Journal of Oral Implantology·Prasun ShahJames Rutkowski
Mar 16, 2002·Journal of Periodontology·Robert W HeroldJames Borke
Aug 27, 2009·Biologics : Targets & Therapy·Neil Ghodadra, Kern Singh
Mar 11, 2016·International Orthopaedics·Antonio FaundezJean-Charles Le Huec
Jun 6, 2012·Advanced Drug Delivery Reviews·Branko TrajkovskiGeorg N Duda
Dec 20, 2016·Orthopedics·Daniel G KangRonald A Lehman
Dec 22, 2016·The Journal of Bone and Joint Surgery. American Volume·Hyun W BaeJeffrey M Toth
Sep 18, 2012·The American Journal of Sports Medicine·Vedran LovricWilliam R Walsh
Feb 4, 2010·The Journal of Bone and Joint Surgery. American Volume·Howard J SeehermanJohn M Wozney
Jun 20, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Naoki NotaniHiroshi Tsumura
Feb 14, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Per BosemarkMagnus Tägil
Jan 1, 2015·Journal of the Korean Association of Oral and Maxillofacial Surgeons·Taek-Kyun KwonSang-Hun Shin
Apr 26, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E AbeS C Manolagas
May 10, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M KanataniK Chihara
Sep 25, 2008·The Journal of Craniofacial Surgery·Darren M SmithJoseph E Losee
Feb 6, 2009·Journal of Biomedical Materials Research. Part a·Ellen WernikeFrank M Klenke
Mar 5, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Steve MinearJill A Helms

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Related Papers

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
P V GiannoudisT A Einhorn
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
H KajiK Chihara
© 2021 Meta ULC. All rights reserved