PMID: 9663646Jul 15, 1998Paper

Stimulatory effect of calcitonin gene-related peptide on adrenocorticotropin release from rat anterior pituitary cells

Journal of Neuroendocrinology
K IinoT Yoshimi

Abstract

In the present study, we examined the direct regulatory effect of rat calcitonin gene-related peptide (CGRP) on adrenocorticotropin (ACTH) release from rat cultured anterior pituitary cells. CGRP significantly increased ACTH release at concentrations of 10(-8)-10(-11) M. The ACTH release was gradually increased by CGRP concentrations lower than 10(-10) M, and was decreased at concentrations higher than 10(-9) M, presenting a bell-shaped dose-response curve. As well as having an additive effect on corticotropin-releasing factor-induced ACTH release, CGRP stimulated the accumulation of intracellular cAMP. The CGRP-induced ACTH release was inhibited by a protein kinase A inhibitor, suggesting that its stimulatory effect on the ACTH release was mediated via an adenylate-cyclase-protein kinase system. CGRP-like immunoreactive nerve fibers have been reported to innervate the anterior pituitary, so that the stimulatory effect of CGRP on the ACTH release suggests that this peptide may be involved in neural regulation of hormone secretion in the anterior pituitary.

References

Sep 30, 1992·Biochemical and Biophysical Research Communications·Y IchikiT Eto
Jan 1, 1992·Pharmacology & Therapeutics·D R Poyner
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·F A TschoppJ A Fischer
Oct 15, 1993·Biochemical and Biophysical Research Communications·C NukiA Wada

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