PMID: 9546610Apr 18, 1998Paper

Stimulatory effect of calcium administration on regucalcin mRNA expression is attenuated in the kidney cortex of rats ingested with saline

Molecular and Cellular Biochemistry
N Shinya, M Yamaguchi

Abstract

The expression of calcium-binding protein regucalcin mRNA in the kidney cortex of rats ingested with saline was investigated. The alteration in regucalcin mRNA levels was analyzed by Northern blotting using liver regucalcin complementary DNA (0.9 kb of open reading frame). Rats were freely given saline as drinking water for 7 days. Regucalcin mRNA levels in the kidney cortex were suppressed by saline ingestion. When calcium chloride (10 mg Ca/100 g body weight) was intraperitoneally administered to rats ingested with saline for 7 days, the effect of calcium administration to increase regucalcin mRNA levels was weakened by saline ingestion. Such effect was also seen by the administration of 2.5 and 5 mg Ca/100 g. Regucalcin mRNA levels in the kidney cortex of spontaneous hypertensive rats (SHR) were not appreciably increased by the administration of calcium (10 mg/100 g). Meanwhile, calcium content in the kidney cortex was significantly elevated by the administration of calcium (10 mg/100 g) to normal rats. This increase was weakened in saline-ingested rats. Moreover, Ca2+/calmodulin-dependent protein kinase activity in the cytosol of kidney cortex was significantly decreased by saline ingestion. These results suggest the possib...Continue Reading

Citations

Mar 25, 2011·Molecular and Cellular Biochemistry·Masayoshi Yamaguchi
Oct 12, 2010·Molecular and Cellular Biochemistry·Masayoshi Yamaguchi
Mar 23, 2013·Cellular and Molecular Life Sciences : CMLS·Ricardo MarquesSílvia Socorro
Mar 7, 2014·Molecular and Cellular Biochemistry·Masayoshi Yamaguchi
Sep 24, 2015·International Journal of Molecular Medicine·Masayoshi Yamaguchi
May 16, 2000·Life Sciences·M Yamaguchi

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