PMID: 9434344Jan 22, 1998Paper

Stimulatory effect of progesterone and 5 beta-progesterone on lipid synthesis in hamster flank organs

Steroids
M Cabeza, R Miranda

Abstract

In order to study lipid synthesis in female hamster flank organs during the estrous cycle, glands were obtained from different animals during different phases of the cycle. Lipid metabolism of [U-14C]glucose was studied under in vitro conditions. The radioactive lipids formed, were extracted from the glands and quantified. An aliquot of the extract was submitted to TLC to isolate and identify the lipids formed. Lipid synthesis in the glands increased significantly during estrous compared with the diestrous phase, suggesting the influence of sex hormones on lipid metabolism in flank organs. The radioactive lipids isolated and identified were: phospholipids, cholesterol, glycerides, waxes, and cholesterol esters. The percentages of conversation from [U-14C]glucose to cholesterol esters were minor in extracts from glands of diestrous animals as compared to estrous and proestrous animals, whereas glycerides and waxes increased significantly in metestrous and diestrous animals. To verify and evaluate the role of estrogen and progesterone in lipid synthesis, three different groups of gonadectomized female hamsters were injected daily with estradiol, progesterone, and 5 alpha-progesterone. After treatments, glands were incubated with ...Continue Reading

References

Jan 1, 1986·Archives of Dermatological Research·C J BedordB M Wagner
Jan 1, 1982·The British Journal of Dermatology·A J VermorkenP Wirtz
Apr 1, 1980·The British Journal of Dermatology·A J VermorkenH M Roelofs

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Citations

Jun 1, 2001·Chemical & Pharmaceutical Bulletin·M CabezaR Martínez
Dec 6, 2005·Chemical & Pharmaceutical Bulletin·Elena RamírezTeresa Ramírez
Apr 3, 2012·Journal of Dermatological Science·Marisa CabezaEugene Bratoeff
Dec 21, 2011·Phytotherapy Research : PTR·Zhiyi QiangSuzanne Hendrich
Feb 6, 2014·Archiv der Pharmazie·Juan C López-LezamaEugene Bratoeff

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