Stimulatory effects of hyperprolactinemia on aldosterone secretion in ovariectomized rats

Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research
Mei-Mei KauPaulus S Wang

Abstract

To evaluate the effects of hyperprolactinemia on aldosterone secretion and its mechanisms of action in ovariectomized (OVX) rats. Hyperprolactinemia was induced by the transplantation of rat anterior pituitary (AP) glands under the kidney capsule for 6 weeks in female rats. Control rats underwent cerebral cortex (CX) transplantation. Four weeks after transplantation, the rats were OVX 2 weeks before decapitation. After decapitation, the trunk blood was collected, and the adrenal glands of CX- and AP-grafted rats were prepared as zona glomerulosa (ZG) cells for in vitro study. Plasma prolactin and aldosterone in the rats were increased by AP gland transplantation. In the in vitro study, the basal aldosterone secretion by the adrenal ZG cells was higher in AP-grafted rats than in CX-grafted rats. The AP-grafted group showed increased responsiveness to angiotensin II (10(-8) M), KCl (8 x 10(-3) M), or 8-bromo-adenosine 3',5'-cyclic monophosphate (8-br-cAMP; 10(-4) M, a membrane-permeable analogue of cAMP) with regard to aldosterone secretion as compared with the CX-grafted group. N-(2-[p-Bromocinnamylamine]ethyl)-5-isoquinolinesulfonamide (H89; 10(-6), 10(-5) M, a protein kinase A inhibitor) or tetrandrine (10(-5) M, a blocker for...Continue Reading

References

Mar 1, 1978·Endocrinology·S J Winters, D L Loriaux
Jul 1, 1990·The Journal of Clinical Endocrinology and Metabolism·B M ArafahJ G Douglas
Nov 1, 1989·Endocrine Reviews·P Q BarrettH Rasmussen
Jan 1, 1986·The Journal of Endocrinology·C Pippard, P H Baylis
Jan 1, 1986·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·P RebuffatG G Nussdorfer
Jan 1, 1988·Annual Review of Physiology·S J Quinn, G H Williams
Dec 1, 1986·Endocrinology·M T RobertsonW V Robertson
Jan 1, 1973·American Journal of Obstetrics and Gynecology·E E BryantA D Ashburn
Sep 1, 1973·Cardiovascular Research·D F HorrobinP G Burstyn
Jul 1, 1983·Journal of Steroid Biochemistry·G Aguilera, K J Catt
Feb 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·C T PrivalleC R Jefcoate
Oct 1, 1981·Proceedings of the Society for Experimental Biology and Medicine·J P McMurtry, B C Wexler
Apr 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·J Müller
Feb 18, 1999·Journal of Cellular Biochemistry·M M KauP S Wang
Mar 24, 1999·Journal of Cellular Biochemistry·M M KauP S Wang
Sep 14, 1999·Metabolism: Clinical and Experimental·M M KauP S Wang

❮ Previous
Next ❯

Citations

Feb 14, 2012·Comptes rendus biologies·Leila Saadi, Nemcha Lebaili
Dec 9, 2008·Metabolism: Clinical and Experimental·Mei-Mei KauShyi-Wu Wang
Dec 1, 2010·Clinical Endocrinology·Paraskevi MediskouJohn G Yovos
May 8, 2007·Genomics·David GerholdMagdalena Alonso-Galicia
Oct 2, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Elise P Gomez-SanchezNaveed Ahmad
May 12, 2005·Journal of Cellular Physiology·Mei-Mei KauPaulus S Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
C de Rouffignac
Molecular and Cellular Endocrinology
Wendy B BollagRoberto A Calle
© 2022 Meta ULC. All rights reserved