Sep 12, 2015

Stimuli reduce the dimensionality of cortical activity

BioRxiv : the Preprint Server for Biology
Luca MazzucatoGiancarlo La Camera

Abstract

The activity of ensembles of simultaneously recorded neurons can be represented as a set of points in the space of firing rates. Even though the dimension of this space is equal to the ensemble size, neural activity can be effectively localized on smaller subspaces. The dimensionality of the neural space is an important determinant of the computational tasks supported by the neural activity. Here, we investigate the dimensionality of neural ensembles from the sensory cortex of alert rats during period of ongoing (inter-trial) and stimulus-evoked activity. We find that dimensionality grows linearly with ensemble size, and grows significantly faster during ongoing activity compared to evoked activity. We explain these results using a spiking network model based on a clustered architecture. The model captures the difference in growth rate between ongoing and evoked activity and predicts a characteristic scaling with ensemble size that could be tested in high-density multi-electrode recordings. Moreover, the model predicts the existence of an upper bound on dimensionality. This upper bound is inversely proportional to the amount of pair-wise correlations and, compared to a homogeneous network without clusters, it is larger by a fac...Continue Reading

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Mentioned in this Paper

Size
Zone of Nerve
Bounded by
Neurons
Sensory Cortex
Anatomical Space Structure
Structure of Cortex of Kidney
Clinical Trials
Specimen Type - Electrode
Gene Clusters

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