Stimuli-responsive metal-organic frameworks gated by pillar[5]arene supramolecular switches

Chemical Science
Li-Li TanYing-Wei Yang

Abstract

Spurred on by recent advances in materials chemistry and drug delivery, a new stimuli-responsive theranostic hybrid platform, based on mechanized monodisperse nano metal-organic frameworks (NMOFs) gated by carboxylatopillar[5]arene (CP5) switches with bio-friendly pH-triggered cargo release capabilities, has been constructed for the first time. This nanoscale smart cargo delivery system showed pH- and/or competitive binding agent-triggered controlled cargo release with negligible premature release, large pore sizes for drug encapsulation, low cytotoxicity, good biodegradability and biocompatibility, and potential application in cell imaging, which offers a new tool in targeted drug delivery and the controlled release of therapeutic agents.

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Citations

May 30, 2019·Chemical Communications : Chem Comm·Jiao ChenYong Yao
Nov 21, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yang WangYuxin Pei
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Sep 30, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xin-Yue LouYing-Wei Yang
Jun 24, 2017·Small·Jia ZhuangChia-Kuang Tsung
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Jun 9, 2018·Angewandte Chemie·Jia-Rui WuYing-Wei Yang

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Methods Mentioned

BETA
transmission
electron-diffraction
electron diffraction
dynamic light scattering

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