Stimuli-Responsive Multilayers Based on Thiolated Polysaccharides That Affect Fibroblast Cell Adhesion

ACS Applied Materials & Interfaces
Pegah EsmaeilzadehThomas Groth

Abstract

Control of the biomaterial properties through stimuli-responsive polymeric platforms has become an essential technique in recent biomedical applications. A multilayer system of thiolated chitosan (t-Chi) and thiolated chondroitin sulfate (t-CS), consisting of five double layers ([t-Chi/t-CS]5), was fabricated here by applying a layer-by-layer coating strategy. To represent a novel class of chemically tunable nanostructures, the ability to cross-link pendant thiol groups was tested by a rise from pH 4 during layer formation to pH 9.3 and a more powerful chemical stimulus by using chloramine-T (ChT). Following both treatments, the resulting multilayers showed stimuli-dependent behavior, as demonstrated by their content of free thiols, wettability, surface charge, elastic modulus, roughness, topography, thickness, and binding of fibronectin. Studies with human dermal fibroblasts further demonstrated the favorable potential of the ChT-responsive multilayers as a cell-adhesive surface compared to pH-induced cross-linking. Because the [t-Chi/t-CS]5 multilayer system is responsive to stimuli such as the pH and redox environment, multilayer systems with disulfide bond formation may help to tailor their interaction with cells, film degr...Continue Reading

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Citations

Jan 16, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Falko DoberenzThomas Groth
Mar 19, 2020·Artificial Organs·Paul S Malchesky
Jun 23, 2020·Biomacromolecules·Christoph FedererAndreas Bernkop-Schnürch
Jan 9, 2019·ACS Applied Materials & Interfaces·Jose D DelgadoJoseph B Schlenoff
Jul 10, 2019·ACS Applied Materials & Interfaces·Pegah Esmaeilzadeh, Thomas Groth

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