Stimuli-responsive nanoscale drug delivery systems for cancer therapy

Journal of Drug Targeting
Li LiDong-Gang Xu

Abstract

Currently, with the rapid development of nanotechnology, novel drug delivery systems (DDSs) have made rapid progress, in which nanocarriers play an important role in the tumour treatment. In view of the conventional chemotherapeutic drugs with many restrictions such as nonspecific systemic toxicity, short half-life and low concentration in the tumour sites, stimuli-responsive DDSs can deliver anti-tumour drugs targeting to the specific sites of tumours. Owing to precise stimuli response, stimuli-responsive DDSs can control drug release, so as to improve the curative effects, reduce the damage of normal tissues and organs, and decrease the side effects of traditional anticancer drugs. At present, according to the physicochemical properties and structures of nanomaterials, they can be divided into three categories: (1) endogenous stimuli-responsive materials, including pH, enzyme and redox responsive materials; (2) exogenous stimuli-responsive materials, such as temperature, light, ultrasound and magnetic field responsive materials; (3) multi-stimuli responsive materials. This review mainly focuses on the researches and developments of these novel stimuli-responsive DDSs based on above-mentioned nanomaterials and their clinical a...Continue Reading

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Citations

Aug 11, 2020·Macromolecular Rapid Communications·Jeaniffer E YapMartina H Stenzel
Dec 29, 2020·Carbohydrate Polymers·Khadijeh SoleimaniHadi Samadian
Sep 18, 2020·International Journal of Pharmaceutics·Elaheh MirhadiMahmoud Reza Jaafari
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Jul 17, 2021·Journal of Nanobiotechnology·Guangman CuiGuangyu Yao
Aug 29, 2021·Pharmaceutics·Kristin Entzian, Achim Aigner
Dec 2, 2021·Advanced Healthcare Materials·Yang YangChangyou Zhan

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