Stimuli-responsive polymeric nanocarriers for the controlled transport of active compounds: concepts and applications

Advanced Drug Delivery Reviews
Emanuel FleigeRainer Haag

Abstract

The use of polymeric nanocarriers to transport active compounds like small-molecular drugs, peptides, or genes found an increased attention throughout the different fields of natural sciences. Not only that these nanocarriers enhance the properties of already existing drugs in terms of solubility, bioavailability, and prolonged circulation times, furthermore they can be tailor-made in such a manner that they selectively release their cargo at the desired site of action. For the triggered release, these so-called smart drug delivery systems are designed to react on certain stimuli like pH, temperature, redox potential, enzymes, light, and ultrasound. Some of these stimuli are naturally occurring in vivo, for example the difference in pH in different cellular compartments while others are caused by the disease, which is to be treated, like differences in pH and temperature in some tumor tissues. Other external applied stimuli, like light and ultrasound, allow the temporal and spatial control of the release, since they are not triggered by any biological event. This review gives a brief overview about some types of stimuli-responsive nanocarriers with the main focus on organic polymer-based systems. Furthermore, the different stim...Continue Reading

References

Sep 18, 1997·Journal of the National Cancer Institute·A F Chambers, L M Matrisian
Jan 16, 1999·The Journal of Biological Chemistry·X M JiangP J Hogg
Oct 26, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E GianasiR Duncan
Mar 22, 2001·Advanced Drug Delivery Reviews·J Kost, R Langer
Nov 16, 2002·Angewandte Chemie·Michael KrämerRainer Haag
Aug 29, 2003·The Journal of Biological Chemistry·N D SonawaneA S Verkman
Nov 20, 2003·Bioconjugate Chemistry·Ryan TomlinsonRuth Duncan
Feb 24, 2004·The Journal of Gene Medicine·Antoine Kichler
Feb 26, 2004·Journal of the American Chemical Society·Kanjiro MiyataKazunori Kataoka
Mar 18, 2004·The Journal of Gene Medicine·Robert C CarlisleLeonard W Seymour
Apr 6, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fariyal Ahmed, Dennis E Discher
Jun 16, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Vinayak P SantJean-Christophe Leroux
Jul 22, 2004·International Journal of Pharmaceutics·Jundong DaiQiang Zhang
Dec 29, 2004·Journal of Drug Targeting·K UlbrichB Ríhová
Jan 18, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zhong-Gao GaoNatalya Rapoport
Jan 20, 2005·Angewandte Chemie·Keren HabaDoron Shabat
Mar 5, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S Moein MoghimiJ Clifford Murray
Mar 30, 2005·Nano Letters·Eun Seong LeeYou Han Bae
May 7, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Alessandro NapoliJeffrey A Hubbell
Jun 9, 2005·Journal of the American Chemical Society·Jinqiang JiangYue Zhao
Jul 14, 2005·Journal of the American Chemical Society·Andrew P GoodwinJean M J Fréchet
Jul 30, 2005·Science·Armagan KoçerBen L Feringa
Aug 2, 2005·Molecular Pharmaceutics·Ashootosh V AmbadeS Thayumanavan
Sep 22, 2005·Bioconjugate Chemistry·Jovita R Tauro, Richard A Gemeinhart
Oct 20, 2005·Journal of the American Chemical Society·Sivakumar V AathimanikandanS Thayumanavan
Nov 22, 2005·Nature Materials·Nobuhiro NishiyamaKazunori Kataoka
Jun 14, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Uwe BorchertStephan Förster
Jul 28, 2006·Biomolecular Engineering·F ChécotS Lecommandoux
Nov 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Cameron C LeeFrancis C Szoka
Nov 10, 2006·Journal of Drug Targeting·Shangjie XuRainer Haag
Nov 28, 2006·Advanced Drug Delivery Reviews·Dirk Schmaljohann
Feb 24, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Michael NeuThomas Kissel
Mar 24, 2007·Nanomedicine : Nanotechnology, Biology, and Medicine·Sushma Kommareddy, Mansoor Amiji
Apr 6, 2007·Journal of the American Chemical Society·Yan LeeKazunori Kataoka
May 15, 2007·Biomacromolecules·Simona CerritelliJeffrey A Hubbell

❮ Previous
Next ❯

Citations

Mar 19, 2013·International Journal of Pharmaceutics·Kacoli Sen, Mahitosh Mandal
Mar 26, 2013·International Journal of Pharmaceutics·U Gianfranco SpizzirriFrancesca Iemma
Jan 12, 2013·Journal of the American Chemical Society·Sebastian WieczorekHans G Börner
Mar 27, 2013·Journal of the American Chemical Society·Pramod P PillaiBartosz A Grzybowski
Jul 9, 2013·Nanoscale·Eric BusseronNicolas Giuseppone
Apr 5, 2014·Nature Communications·Kevin A CarterJonathan F Lovell
Feb 21, 2014·Chemical Communications : Chem Comm·Zhengze YuBo Tang
Mar 26, 2014·The Analyst·Anna KisielAgata Michalska
Apr 15, 2014·Biomacromolecules·Susanne FehseGerd Multhaup
Dec 21, 2013·Nanomedicine·Charles FortierGregory De Crescenzo
Dec 7, 2013·Therapeutic Delivery·Xi HeChen Jiang
Nov 15, 2012·Future Oncology·Pengxiao Cao, Younsoo Bae
Sep 13, 2013·Therapeutic Delivery·Kyrillus S Shohdy, Ahmad Samir Alfaar
Nov 16, 2013·Therapeutic Delivery·James B DelehantyIgor L Medintz
Jan 12, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wei ChenZhiyuan Zhong
Apr 29, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Emanuel FleigeRainer Haag
Aug 27, 2013·Journal of Materials Science. Materials in Medicine·Victor R de la Rosa
Nov 26, 2013·Advanced Drug Delivery Reviews·Swati Biswas, Vladimir P Torchilin
Dec 25, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Dirk SteinhilberRainer Haag
May 2, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wan WangJ Andrew MacKay
Dec 3, 2014·Annales pharmaceutiques françaises·D Le Cerf
Dec 11, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Yang HuChengyou Kan
Feb 10, 2016·Colloids and Surfaces. B, Biointerfaces·Jiaming ChenLi-Qun Wang
Feb 2, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Magdalena PrzybyloMarek Langner
Sep 24, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anjali Sharma, Ashok Kakkar
Oct 17, 2015·International Journal of Environmental Research and Public Health·Patrick KellyMandë Holford
Feb 20, 2014·Drug Delivery·Bita TaghizadehZaynab Derakhshani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Related Papers

Journal of Controlled Release : Official Journal of the Controlled Release Society
Srinivas GantaMansoor Amiji
Journal of Controlled Release : Official Journal of the Controlled Release Society
Eun Seong LeeYou Han Bae
© 2022 Meta ULC. All rights reserved