PMID: 15383599Sep 24, 2004Paper

Stimulus-dependent requirement for granulocyte-macrophage colony-stimulating factor in inflammation

The Journal of Immunology : Official Journal of the American Association of Immunologists
Andrew D CookJohn A Hamilton

Abstract

Data from several inflammation/autoimmunity models indicate that GM-CSF can be a key inflammatory mediator. Convenient models in readily accessible tissues are needed to enable the GM-CSF-dependent cellular responses to be elaborated. In this study, we show that, in contrast to the response to the commonly used i.p. irritant, thioglycolate medium, an Ag-specific methylated BSA-induced peritonitis in GM-CSF(-/-) mice was severely compromised. The reduced response in the latter peritonitis model was characterized by fewer neutrophils and macrophages, as well as by deficiencies in the properties of the remaining macrophages, namely size and granularity, phagocytosis, allogeneic T cell triggering, and proinflammatory cytokine production. B1 lymphocytes were more evident in the GM-CSF(-/-) Ag-specific exudates, indicating perhaps that GM-CSF can act on a common macrophage-B1 lymphocyte precursor in the inflamed peritoneum. We propose that these findings contribute to our understanding of how GM-CSF acts as a proinflammatory cytokine in many chronic inflammatory/autoimmune diseases. Of general significance, the findings also indicate that the nature of the stimulus is quite critical in determining whether a particular inflammatory me...Continue Reading

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Citations

Jul 22, 2005·Journal of the American Society of Nephrology : JASN·Jennifer R TimoshankoPeter G Tipping
Aug 24, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alice O KamphorstMichel C Nussenzweig
Jul 6, 2011·Immunology and Cell Biology·Jason C LenzoJohn A Hamilton
Mar 23, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ian K CampbellIan P Wicks
Aug 17, 2011·Immunology and Cell Biology·Doris S C ShimWilliam A Sewell
Jan 25, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jinwook ShinXiao-Ping Zhong
Feb 19, 2017·Seminars in Immunopathology·Mélissa Noack, Pierre Miossec
May 29, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kevin M-C LeeAndrew Cook
Feb 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yung-Chang SuWilliam A Sewell
Nov 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuekang XuMichael H Kershaw
Oct 27, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lachlan M MoldenhauerSarah A Robertson
Jul 18, 2015·PloS One·Chien-Chiao HuangTian-Lu Cheng
Aug 6, 2019·The Journal of Clinical Investigation·Li XuMeihong Deng
Dec 5, 2008·Expert Review of Anti-infective Therapy·Thomas Kruse, Hans-Henrik Kristensen
Nov 18, 2009·Proceedings of the National Academy of Sciences of the United States of America·Elodie SeguraJosé A Villadangos
Apr 4, 2015·Mediators of Inflammation·Aoi Shiomi, Takashi Usui
Apr 17, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ming-Chin LeeAndrew D Cook
Sep 26, 2019·Frontiers in Immunology·John A Hamilton
Jun 14, 2008·Nature Reviews. Immunology·John A Hamilton
May 9, 2006·Nature Immunology·Shalin H NaikKen Shortman
Apr 5, 2011·Allergy, Asthma & Immunology Research·Nami Shrestha PalikheHae-Sim Park
Mar 23, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ming-Chin LeeAndrew D Cook
Oct 16, 2019·The Journal of Experimental Medicine·John A Hamilton
May 29, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cynthia LouisJohn A Hamilton
Oct 16, 2015·Biogerontology·Mirjana DimitrijevićGordana Leposavić
Dec 24, 2013·The Journal of Experimental Biology·William B Bryant, Kristin Michel
Sep 5, 2012·Molecular Immunology·Wei XuCees van Kooten
Jul 6, 2021·Frontiers in Immunology·Joseph W Fischer, Nirjal Bhattarai

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