Stimulus information stored in lasting active and hidden network states is destroyed by network bursts

Frontiers in Integrative Neuroscience
Mark R DraniasAntonius M J VanDongen

Abstract

In both humans and animals brief synchronizing bursts of epileptiform activity known as interictal epileptiform discharges (IEDs) can, even in the absence of overt seizures, cause transient cognitive impairments (TCI) that include problems with perception or short-term memory. While no evidence from single units is available, it has been assumed that IEDs destroy information represented in neuronal networks. Cultured neuronal networks are a model for generic cortical microcircuits, and their spontaneous activity is characterized by the presence of synchronized network bursts (SNBs), which share a number of properties with IEDs, including the high degree of synchronization and their spontaneous occurrence in the absence of an external stimulus. As a model approach to understanding the processes underlying IEDs, optogenetic stimulation and multielectrode array (MEA) recordings of cultured neuronal networks were used to study whether stimulus information represented in these networks survives SNBs. When such networks are optically stimulated they encode and maintain stimulus information for as long as one second. Experiments involved recording the network response to a single stimulus and trials where two different stimuli were pr...Continue Reading

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Citations

Oct 30, 2016·Current Opinion in Behavioral Sciences·Nicholas F Hardy, Dean V Buonomano
Apr 12, 2016·Frontiers in Systems Neuroscience·Yuichiro YadaHirokazu Takahashi
Sep 12, 2015·Epilepsy Research·Mingrui ZhaoTheodore H Schwartz

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BETA
transfection

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Neuroshare API
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MATLAB
MC

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