Stimulus intensity-dependent modulations of hippocampal long-term potentiation by basolateral amygdala priming.

Frontiers in Cellular Neuroscience
Zexuan Li, Gal Richter-Levin

Abstract

There is growing realization that the relationship between memory and stress/emotionality is complicated, and may include both memory enhancing and memory impairing aspects. It has been suggested that the underlying mechanisms involve amygdala modulation of hippocampal synaptic plasticity, such as long-term potentiation (LTP). We recently reported that while in CA1 basolateral amygdala (BLA) priming impaired theta stimulation induced LTP, it enhanced LTP in the dentate gyrus (DG). However, emotional and stressfull experiences were found to activate synaptic plasticity within the BLA, raising the possibility that BLA modulation of other brain regions may be altered as well, as it may depend on the way the BLA is activated or is responding. In previous studies BLA priming stimulation was relatively weak (1 V, 50 μs pulse duration). In the present study we assessed the effects of two stronger levels of BLA priming stimulation (1 V or 2 V, 100 μs pulse duration) on LTP induction in hippocampal DG and CA1, in anesthetized rats. Results show that 1V-BLA priming stimulation enhanced but 2V-BLA priming stimulation impaired DG LTP; however, both levels of BLA priming stimulation impaired CA1 LTP, suggesting that modulation of hippocampa...Continue Reading

Citations

Sep 4, 2013·Hormones and Behavior·Matthew R Green, Cheryl M McCormick
Dec 26, 2012·Neurobiology of Learning and Memory·Candice M ChavezNorman M Weinberger
Apr 22, 2014·Neurobiology of Learning and Memory·MingXin FaGal Richter-Levin
Dec 27, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·W N Marsden
Apr 23, 2013·Trends in Neurosciences·Sarah R HulmeWickliffe C Abraham
Dec 4, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Sarah R HulmeWickliffe C Abraham
Apr 29, 2015·Reviews in the Neurosciences·Deepika Suri, Vidita A Vaidya
Aug 12, 2015·Stress : the International Journal on the Biology of Stress·Aline DesmedtLudovic Calandreau
Jul 25, 2021·Neurobiology of Learning and Memory·Rafael RoeslerChrista K McIntyre

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