Stimulus processing of glycine is dissociable from that of sucrose and glucose based on behaviorally measured taste signal detection in Sac 'taster' and 'non-taster' mice

Chemical Senses
Shachar Eylam, Alan C Spector

Abstract

Mouse strains have been divided into 'tasters' and 'non-tasters' based on their relatively high and low preference, respectively, for low concentrations of sucrose and saccharin. These phenotypic differences appear to be due to a polymorphism in the gene at the Sac locus encoding for the T1R3 taste receptor selectively affecting the functionality of the T1R2+3 heterodimer. To psychophysically examine whether these phenotypes are due to sensory sensitivity as opposed to hedonic responsiveness, we measured taste signal detection of sucrose, glucose, and glycine by Sac taster (C57BL/6J and SWR/J) and non-taster (129P3/J and DBA/2J) strains in an operant conditioning paradigm using a gustometer. The taster mice had lower detection thresholds for sucrose and glucose compared with the non-taster mice. The detection thresholds corresponded well with reported responsiveness to low concentrations of these sugars in two-bottle intake tests suggesting that the Sac taster phenotype has a sensory basis and is not simply a matter of strain differences in the hedonic evaluation of weak intensities of the stimuli. Taster status did not entirely account for the strain differences in detection thresholds for glycine, a 'sweet' tasting amino acid...Continue Reading

Citations

Aug 12, 2006·Chemical Senses·Satoshi ManitaMasashi Inoue
May 25, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yada Treesukosol, Alan C Spector
Dec 19, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Steven ZukermanAnthony Sclafani
Mar 13, 2009·Journal of Neurophysiology·Christian H Lemon, Robert F Margolskee
Oct 18, 2007·BMC Neuroscience·John D Boughter, Alexander A Bachmanov
Sep 24, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yada TreesukosolAlan C Spector
Mar 8, 2011·Physiology & Behavior·Yada TreesukosolAlan C Spector
Aug 12, 2008·Physiology & Behavior·John I GlendinningRouane Bayor
May 24, 2008·Neuroscience and Biobehavioral Reviews·Stuart A McCaughey
May 2, 2006·Physiology & Behavior·Anthony Sclafani
Apr 22, 2015·Physiology & Behavior·Alan C Spector
Aug 11, 2011·Physiology & Behavior·M BueterC W le Roux
Jan 27, 2015·Chemical Senses·Alan C SpectorJames A Donaldson
Feb 15, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ginger D BlondeAlan C Spector
Apr 23, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Anthony Sclafani, John I Glendinning
Sep 2, 2005·Chemical Senses·John I GlendinningKun Hao Zheng
Nov 4, 2005·Chemical Senses·Susan M BrasserDavid V Smith
Jul 12, 2011·Flavour and Fragrance Journal·Alexander A BachmanovGary K Beauchamp
Jun 7, 2012·American Journal of Physiology. Endocrinology and Metabolism·Maartje C P GeraedtsSteven D Munger
Jan 10, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lindsey A SchierAlan C Spector
Jul 6, 2010·Physiology & Behavior·John I GlendinningAnthony Sclafani

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