Stimulus-related neuroimaging in task-engaged subjects is best predicted by concurrent spiking

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Bruss LimaAniruddha Das

Abstract

The implicit goal of functional magnetic resonance imaging is to infer local neural activity. There is considerable debate, however, as to whether imaging correlates most linearly with local spiking or some local field potential (LFP) measurement. Through simultaneous neuroimaging (intrinsic-signal optical imaging) and electrode recordings from alert, task-engaged macaque monkeys, we showed previously that local electrophysiology correlates with only a specific stimulus-related imaging component. Here we show that this stimulus-related component--obtained by subtracting a substantial task-related component--is particularly linear with local spiking over a comprehensive range of response strengths. Matches to concurrent LFP measurements are, to varying degrees, poorer. As a control, we also tried matching the full imaging signal to local electrophysiology without subtracting task-related components. These control matches were consistently worse; they were, however, slightly better for gamma LFP than spiking, potentially resolving discrepancies between our findings and earlier reports favoring LFP.

Citations

Dec 26, 2015·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Jonas LarssonAdam Kohn
Oct 7, 2015·Frontiers in Human Neuroscience·Morgan NewhoffPeter N Steinmetz
May 6, 2015·Current Biology : CB·Joerg F Hipp, Markus Siegel
Mar 15, 2015·Trends in Cognitive Sciences·Thomas C SpragueJohn T Serences
Nov 3, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Florian SchmidAlbrecht Stroh
Apr 20, 2019·PLoS Biology·Mariana M B CardosoAniruddha Das
Jun 2, 2018·Scientific Reports·Elena V OrekhovaTatiana A Stroganova
Feb 6, 2020·Archives of Sexual Behavior·Anastasios ZiogasAndreas Mokros
Dec 27, 2016·Frontiers in Neural Circuits·Hisashi TanigawaAnna W Roe
Dec 20, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Niranjan Khadka, Marom Bikson
Nov 17, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Aniruddha DasPatrick J Drew
Jul 16, 2021·PLoS Biology·Qingguang ZhangPatrick J Drew

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