Stimulus-related neuroimaging in task-engaged subjects is best predicted by concurrent spiking

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Bruss LimaAniruddha Das


The implicit goal of functional magnetic resonance imaging is to infer local neural activity. There is considerable debate, however, as to whether imaging correlates most linearly with local spiking or some local field potential (LFP) measurement. Through simultaneous neuroimaging (intrinsic-signal optical imaging) and electrode recordings from alert, task-engaged macaque monkeys, we showed previously that local electrophysiology correlates with only a specific stimulus-related imaging component. Here we show that this stimulus-related component--obtained by subtracting a substantial task-related component--is particularly linear with local spiking over a comprehensive range of response strengths. Matches to concurrent LFP measurements are, to varying degrees, poorer. As a control, we also tried matching the full imaging signal to local electrophysiology without subtracting task-related components. These control matches were consistently worse; they were, however, slightly better for gamma LFP than spiking, potentially resolving discrepancies between our findings and earlier reports favoring LFP.


Dec 26, 2015·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Jonas LarssonAdam Kohn
Oct 7, 2015·Frontiers in Human Neuroscience·Morgan NewhoffPeter N Steinmetz
May 6, 2015·Current Biology : CB·Joerg F Hipp, Markus Siegel
Mar 15, 2015·Trends in Cognitive Sciences·Thomas C SpragueJohn T Serences
Nov 3, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Florian SchmidAlbrecht Stroh
Apr 20, 2019·PLoS Biology·Mariana M B CardosoAniruddha Das
Jun 2, 2018·Scientific Reports·Elena V OrekhovaTatiana A Stroganova
Feb 6, 2020·Archives of Sexual Behavior·Anastasios ZiogasAndreas Mokros
Dec 27, 2016·Frontiers in Neural Circuits·Hisashi TanigawaAnna W Roe
Dec 20, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Niranjan Khadka, Marom Bikson
Nov 17, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Aniruddha DasPatrick J Drew
Jul 16, 2021·PLoS Biology·Qingguang ZhangPatrick J Drew

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.