Stimulus-response and response-outcome learning mechanisms in the striatum.

Behavioural Brain Research
J C Horvitz

Abstract

While midbrain DA neurons show phasic activations in response to both reward-predicting and salient non-reward events, activation responses to primary and conditioned rewards are sustained for several hundreds of milliseconds beyond those elicited by salient non-reward-related stimuli. The longer-duration DA reward response and corresponding elevated DA release in striatal target sites may selectively strengthen currently-active corticostriatal synapses, i.e., those associated with the successful reward-procuring behavior. This paper describes how similar models of DA-mediated plasticity of corticostriatal synapses may describe both stimulus-response and response-outcome learning. DA-mediated strengthening of corticostriatal synapses in regions of the dorsolateral striatum receiving afferents from primary sensorimotor cortex is likely to bind corticostriatal inputs representing the previously-emitted movement to striatal outputs contributing to the selection of the next movement segment in a behavioral sequence. Within the striatum, more generally, inputs from distinct regions of the frontal cortex that code independently for movement direction and reward expectation send convergent projections to striatal output cells. DA-medi...Continue Reading

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Citations

Dec 17, 2009·Behavioral Neuroscience·Won Yung ChoiJon C Horvitz
Oct 15, 2010·Nature Reviews. Neuroscience·Peter RedgraveJose A Obeso
Mar 4, 2011·Journal of Neurophysiology·Collin J LobbCarlos A Paladini
Nov 15, 2011·Neural Networks : the Official Journal of the International Neural Network Society·Henning SchrollFred H Hamker
Jun 28, 2011·Progress in Neurobiology·Michael W Shiflett, Bernard W Balleine
Mar 9, 2010·Trends in Cognitive Sciences·F Gregory AshbyJon C Horvitz
Dec 17, 2009·Neurobiology of Disease·David A PetersonHoward Poizner
Dec 29, 2009·Behavioural Brain Research·Patrick Anselme
Nov 10, 2009·Current Opinion in Neurobiology·Mati JoshuaHagai Bergman
Nov 4, 2008·Behavioural Brain Research·Claudio Da CunhaEdmar Miyoshi
Oct 21, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Morvarid KarimiJoel S Perlmutter
Jul 6, 2013·Neurobiology of Learning and Memory·Milica CerovicRiccardo Brambilla
Dec 15, 2010·Behavioural Brain Research·Michael W Shiflett, Bernard W Balleine
Jan 24, 2018·The European Journal of Neuroscience·Michael V BarattaSteven F Maier
Jul 25, 2019·The European Journal of Neuroscience·Veronica DobrovitskyJon C Horvitz
Sep 17, 2020·Learning & Memory·Yi-Wen Wang, F Gregory Ashby
Mar 23, 2017·Frontiers in Computational Neuroscience·David A Peterson, Terrence J Sejnowski

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