Stimulus-response compatibility in Huntington's disease: a cognitive-neurophysiological analysis

Journal of Neurophysiology
Christian BesteMichael Falkenstein

Abstract

The basal ganglia are assumed to be of importance in action/response selection, but results regarding the importance are contradictive. We investigate these processes in relation to attentional processing using event-related potentials (ERPs) in Huntington's disease (HD), an autosomal genetic disorder expressed by degeneration of the basal ganglia, using a flanker task. A symptomatic HD group, a presymptomatic HD group (pHD), and healthy controls were examined. In the behavioral data, we found a general response slowing in HD while the compatibility effect was the same for all groups. The ERP data show a decrease of the N1 on the flanker in HD and pHD; this suggests deficient attentional processes. The N1 on the target was unaffected, suggesting that the attentional system in HD is not entirely deficient. The early lateralized readiness potential (LRP), reflecting automatic response activation due to the flankers, was unchanged, whereas the late LRP, reflecting controlled response selection due to the target information, was delayed in HD. Thus levels of action-selection processes are differentially affected in HD with automatic processes seeming to be more robust against neurodegeneration. The N2, usually associated with confl...Continue Reading

References

Jun 1, 1991·Electroencephalography and Clinical Neurophysiology·M FalkensteinL Blanke
Apr 1, 1983·Electroencephalography and Clinical Neurophysiology·G GrattonE Donchin
Apr 1, 1995·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·J L Nandrino, F el Massioui
Nov 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·M JahanshahiC D Marsden
Mar 1, 1996·Movement Disorders : Official Journal of the Movement Disorder Society
Oct 6, 1997·Brain : a Journal of Neurology·P BartensteinB Conrad
Mar 21, 1998·Psychophysiology·H Leuthold, W Sommer
Mar 17, 1999·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·J D Kropotov, S C Etlinger
Sep 24, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·P PraamstraM W Horstink
Mar 22, 2000·Nature Neuroscience·F BarcelóR T Knight
Jun 14, 2000·Progress in Neurobiology·I J MitchellM R Griffiths
Oct 12, 2001·Neuroscience and Biobehavioral Reviews·C S Herrmann, R T Knight
Jul 24, 2002·Brain : a Journal of Neurology·M J ThiebenR S J Frackowiak
Jan 16, 2003·Physiology & Behavior·Vincent van Veen, Cameron S Carter
Nov 7, 2003·Biological Psychology·Daniel H MathalonJudith M Ford
Mar 12, 2004·Progress in Neurobiology·Izhar Bar-GadHagai Bergman
Apr 13, 2004·Neuroreport·Jan KassubekAlexander Peinemann
Jun 3, 2004·Annals of Neurology·Sarah A J ReadingChristopher A Ross
Oct 16, 2004·Psychological Review·Nick YeungJonathan D Cohen
Nov 24, 2004·Trends in Cognitive Sciences·Matthew M BotvinickCameron S Carter
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·H D RosasSteven M Hersch
Feb 9, 2006·Journal of Neural Transmission·M FalkensteinH Hielscher
Mar 1, 2006·Brain : a Journal of Neurology·Kathrin FinkeWerner X Schneider
Jun 30, 2006·Psychophysiology·Allen AzizianNancy K Squires
Dec 16, 2006·Progress in Neurobiology·Carlos CepedaMichael S Levine
Dec 22, 2006·PloS One·Christian BesteMichael Falkenstein

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Citations

Feb 9, 2012·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Nellie Georgiou-KaristianisDianne M Sheppard
Feb 12, 2010·Journal of Cognitive Neuroscience·Sarah E ForsterRaymond Y Cho
May 17, 2014·Neurodegenerative Disease Management·Isabella Maria Sophie Mayer, Michael Orth
Jun 21, 2014·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Michael J LarsonAnn Clawson
Jan 28, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·R J CroftN Georgiou-Karistianis
Jan 25, 2016·Brain Structure & Function·Rui ZhangChristian Beste
Dec 3, 2011·Brain and Cognition·Sebastian OcklenburgChristian Beste
Sep 29, 2009·Neuropsychologia·Christian BesteMichael Falkenstein
Jan 1, 2015·Nature Reviews. Disease Primers·Gillian P BatesSarah J Tabrizi
Nov 14, 2016·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Ann-Kathrin StockChristian Beste
Feb 12, 2017·NeuroImage·Nura SidarusPatrick Haggard
Apr 1, 2018·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Nicole WolffChristian Beste
Dec 25, 2009·Journal of Neurophysiology·Edmund Wascher, Christian Beste
Feb 6, 2016·Vestnik oftalmologii·S N SvetozarskiyI G Smetankin
Dec 19, 2019·Frontiers in Neuroscience·Satoshi Nonomura, Kazuyuki Samejima
Dec 3, 2020·Scientific Reports·Claudia C SchmidtPeter H Weiss
Mar 20, 2021·NeuroImage. Clinical·Emily MielkeAlexander Münchau
Jun 29, 2021·Psychophysiology·Lu JiaoBaoguo Chen

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